Creation of a mouse expressing defective human factor IX
about
Animal models of hemophiliaCurrent animal models of hemophilia: the state of the artUltrasound-targeted hepatic delivery of factor IX in hemophiliac mice.Qualitative disorders of platelets and megakaryocytes.Toward Personalized Gene Therapy: Characterizing the Host Genetic Control of Lentiviral-Vector-Mediated Hepatic Gene Delivery.Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application.Identification of a novel Gig2 gene family specific to non-amniote vertebrates.The promise and challenges of bioengineered recombinant clotting factors.A guide to murine coagulation factor structure, function, assays, and genetic alterations.In vivo models of haemophilia - status on current knowledge of clinical phenotypes and therapeutic interventions.Animal models of hemophilia and related bleeding disorders.Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice.Long-term expression of human coagulation factor VIII in a tolerant mouse model using the φC31 integrase system.Generation of a novel factor IX with augmented clotting activities in vitro and in vivo.Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.Genetic modification of donor hepatocytes improves therapeutic efficacy for hemophilia B in mice.Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.Long-term phenotypic correction in factor IX knockout mice by using ΦC31 integrase-mediated gene therapy.The F8(-/-) rat as a model of hemophilic arthropathy.Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.
P2860
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P2860
Creation of a mouse expressing defective human factor IX
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2004
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im September 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/09/15)
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vědecký článek publikovaný v roce 2004
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wetenschappelijk artikel (gepubliceerd op 2004/09/15)
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наукова стаття, опублікована у вересні 2004
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مقالة علمية (نشرت في 15-9-2004)
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name
Creation of a mouse expressing defective human factor IX
@ast
Creation of a mouse expressing defective human factor IX
@en
Creation of a mouse expressing defective human factor IX
@nl
type
label
Creation of a mouse expressing defective human factor IX
@ast
Creation of a mouse expressing defective human factor IX
@en
Creation of a mouse expressing defective human factor IX
@nl
prefLabel
Creation of a mouse expressing defective human factor IX
@ast
Creation of a mouse expressing defective human factor IX
@en
Creation of a mouse expressing defective human factor IX
@nl
P2093
P3181
P1433
P1476
Creation of a mouse expressing defective human factor IX
@en
P2093
Da-Yun Jin
Darrel W. Stafford
Paul E. Monahan
Tai-Ping Zhang
P304
P3181
P356
10.1182/BLOOD-2004-01-0138
P407
P577
2004-09-15T00:00:00Z