Pharmacological chaperone for the structured domain of human prion protein.
about
Emerging novel concept of chaperone therapies for protein misfolding diseasesThe prion protein binds thiamineDynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sitesAbrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replication.A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.Structural plasticity of the cellular prion protein and implications in health and disease.Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion proteinQuinacrine promotes replication and conformational mutation of chronic wasting disease prions.Identification of Anti-prion Compounds using a Novel Cellular Assay.Mammalian prions and their wider relevance in neurodegenerative diseases.The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies.Synthesis of an (11) C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography.Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay.Prediction of antiprion activity of therapeutic agents with structure-activity models.Soluble Aβ aggregates can inhibit prion propagation.Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies.Targeting the cellular prion protein to treat neurodegeneration.Pharmacological Agents Targeting the Cellular Prion Protein.
P2860
Q27002907-B5D22716-6355-437C-9B92-B1FBC33A46AFQ27671805-2F36766E-CF5E-44E4-B1B4-3D23C7CC595EQ33892707-8A51CDA3-E36C-4929-A14B-9049823061DCQ34307103-26DEDD26-A7CB-417D-AE8A-FEE69DF491E1Q35145020-4CD63046-A339-4171-B881-73CEC2ED1754Q35166748-0FB0E5F4-EBCE-41BE-AEB6-0E5F05585296Q35562607-ADE5A88F-08BB-4111-8E5A-0F7C01E70900Q36686430-B5F767DE-55DB-41AF-BAC4-D85EA269B12BQ36884143-7227DCAA-4832-4753-A6A1-8E2608A81A35Q37060996-8132152E-23C3-42F2-86A8-7686C9DF0408Q37725318-B792D3F9-2EC1-4C55-BC05-F6EE7BC66814Q38734225-DCC89A5F-0DAC-4997-810D-04AF496EFCA0Q39004344-3FD1DA0F-97DA-48D3-BCD6-92DC1EF9F57DQ39441257-AE4D87EB-35D5-44ED-A1BE-E32D1FB274D8Q42261396-4D53E98E-6DE6-4778-A0AD-ABB15F945E23Q42350107-C5586820-1FE7-46F7-9F83-9F2F42AC530EQ43966734-DA687802-A12D-4EAA-B3A1-0FC605DFD8FEQ47104343-D250DB79-C346-465C-B3C0-C079C9F16B8EQ47294251-6D160B55-4B34-4D64-BA6F-249C003489CEQ51563560-C3E67F69-275B-4F2A-AD7A-C1ECF2EC2E2DQ52666286-9FA740A4-2FDF-4452-8445-B8BDC24F52A0
P2860
Pharmacological chaperone for the structured domain of human prion protein.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Pharmacological chaperone for the structured domain of human prion protein.
@ast
Pharmacological chaperone for the structured domain of human prion protein.
@en
Pharmacological chaperone for the structured domain of human prion protein.
@nl
type
label
Pharmacological chaperone for the structured domain of human prion protein.
@ast
Pharmacological chaperone for the structured domain of human prion protein.
@en
Pharmacological chaperone for the structured domain of human prion protein.
@nl
prefLabel
Pharmacological chaperone for the structured domain of human prion protein.
@ast
Pharmacological chaperone for the structured domain of human prion protein.
@en
Pharmacological chaperone for the structured domain of human prion protein.
@nl
P2093
P2860
P921
P356
P1476
Pharmacological chaperone for the structured domain of human prion protein
@en
P2093
Amaurys Avila Ibarra
Andrew J Nicoll
Anthony R Clarke
Clare R Trevitt
Connor Wright
Emma Quarterman
Emmanuel Risse
John Collinge
M Howard Tattum
Mark Farrow
P2860
P304
17610-17615
P356
10.1073/PNAS.1009062107
P407
P577
2010-09-27T00:00:00Z