Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. - Wikidata - wikimedia - TriplyDB

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

http://www.wikidata.org/entity/Q34200930

about

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease Alternative fuels for cancer cells Regulation of monocarboxylic acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cells Reexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations The ever-expanding role of HIF in tumour and stromal biology ROS homeostasis and metabolism: a critical liaison for cancer therapy Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Cancer: fundamentals behind pH targeting and the double-edged approach Droplet Microfluidic Platform for the Determination of Single-Cell Lactate Release.Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors Radiation induces senescence and a bystander effect through metabolic alterations Dose-Response of High-Intensity Training (HIT) on Atheroprotective miRNA-126 Levels.Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival Cell surface lactate receptor GPR81 is crucial for cancer cell survival.Hyperbaric oxygen, vasculogenic stem cells, and wound healing.Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling.Tumor metabolism, cancer cell transporters, and microenvironmental resistance.Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain.Monocarboxylate transporter 1 inhibitors as potential anticancer agents L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis.L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor.Lactate does not activate NF-κB in oxidative tumor cells Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.The Emerging Hallmarks of Cancer Metabolism Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122.Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A.Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness.Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.Monocarboxylate transporters in the brain and in cancer.

P2860

Q21133953-45712CA0-3378-4039-9782-5601AD791614 Q26745503-1E6EB7BB-6D8A-491A-A3AF-FD97BF422B4A Q26859449-E2F159A5-0682-46E0-8B2E-BEEDDF2704E0 Q26997591-693AEDE7-7F51-4820-B61E-7DEEE7ED78E6 Q27332278-9C97AF0E-FD41-4E6F-9D5E-0680F4863371 Q28077883-30B26F23-F39A-46A9-B46A-D0D115717D4E Q28078370-AEBDC177-E6F2-4C64-A00C-3A9DBD776658 Q28079015-39E9D71B-A58D-4B91-841E-37A04CEAC73D Q28080316-BCA8D867-E1CE-4ED3-9663-DF7E958C1941 Q28081811-E3EF27B7-D36A-407C-B9DA-FFA1BD33D2C5 Q28821351-3BAB77BB-34D3-4D17-A54A-4900D1D1139F Q30734408-690914F7-EEF8-486C-8E72-CD0F1538224E Q33648519-D0EAD974-9BC4-4F26-B0F3-772502F2ADAA Q33720314-E007D078-9FF4-4467-81AF-916F61FD7DEB Q33736756-237EBB7B-C63E-46E0-81D3-C41258402570 Q34194681-A9EC5559-71C0-4D7C-BAB3-B43BD82836BA Q34203416-9CB986E5-0144-432A-9EEA-61F692F2CC3B Q34243400-8A6B3B68-8E59-49BB-B56B-DE37A478A6A7 Q34447189-F3A0BE6B-40CC-4DBE-A9F3-45A728615CC0 Q34513382-945DC738-6FF5-40FD-99D9-27CEBD83A3EA Q34744489-EEF8B13D-4096-4307-B6D0-B928EA35D391 Q34999491-052E4375-F581-4FEA-BB40-18A4D15108AE Q35161318-7B32A40A-DD28-496C-BD1B-6D9608E1A1BE Q35550785-4A71CCA4-E69E-4FE0-A425-39C075C4A8C9 Q35615147-F7B9B569-3EE3-4FAC-ACA2-1413A3A53D3A Q35773497-0483E7B0-B577-430C-A010-9CF84CB1D9ED Q35888916-718A9358-222D-431C-839E-27AADDC2B4B4 Q36125255-48BBA08F-ECC9-4073-A542-E01EBE1C802B Q36149654-E4B985EB-3E54-4350-8115-52C2476D8741 Q36202583-DFAF7861-00B9-4F51-9AC2-04C9443DDDD4 Q36468964-B995CD89-76EF-47CD-93C5-6063E5676F0F Q36545721-51D8DE5D-FB72-43CA-9C76-5134F1F28EE1 Q36562175-ED2B91E4-F342-4572-AE6C-D3251FCCB11F Q36781200-2C80C6A7-89DF-48BF-AAF5-3F22C1271F44 Q36815271-4500F4F9-F860-4AE8-B5F8-6C7FDBBD2754 Q36872785-4FC94202-DFE5-4DE1-9302-84801CE55DE3 Q36906195-72F12001-896A-47AF-A261-5854CA1D241F Q37091959-DCCC8344-CF5E-46FE-819E-467BE6AE3A97 Q37175153-5AA45C1F-A619-4488-911F-2C12A65A0AC7 Q37187094-B0C3B977-BE1F-460C-80EE-E09720C546E3

P2860

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

http://www.wikidata.org/entity/Q34200930

description

2012 nî lūn-bûn

@nan

2012 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մարտին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@ast

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@en

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@nl

type

label

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@ast

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@en

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@nl

prefLabel

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@ast

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@en

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@nl

P1433

Q34200930-4EB22547-5F97-47BB-AFDE-78C52F89E0A9

P1476

Q34200930-B877132D-2AD8-4B4E-B84B-CE657AE185F9

P2093

Q34200930-2433BD31-471F-4899-8DC5-C29B328A8F2E

Q34200930-6D2716A8-5F3C-4408-9B1B-4E01DC66F0A3

Q34200930-72DB44D6-62C5-470C-8E16-4D0FDB53BD9C

Q34200930-79CDCF01-2288-421A-9E8E-65791F949FAC

Q34200930-826230E0-E8EC-4028-AEA9-27D58B337C3C

Q34200930-8742228E-A122-40B8-81F2-3BB9B3B6B918

Q34200930-8FB5977C-EAEE-457F-B0C5-80DA5F29C49A

Q34200930-A623A58A-BABE-47C8-A747-E3E0327CA003

Q34200930-EAA0BED7-AB9C-4C99-B24F-8134CA75049D

Q34200930-FCA742DC-D0A5-4C0C-A826-FCFE7304C864

P2860

Q34200930-00291029-FE47-4D49-840D-8EE7487C1BA9

Q34200930-0A9358F2-06BC-4365-86C0-FA82836BC62B

Q34200930-1A7091B1-4255-4E59-AD92-359AE2A4AB81

Q34200930-1F2C4641-BE57-4FE2-8345-C237A661DDD5

Q34200930-22457714-FAE3-4C88-8D7E-300E5A278AEC

Q34200930-253EBAFD-869F-4FA2-A138-A8ECE0762AAE

Q34200930-2BB3E706-BBF1-40DC-8E9C-F2A59FF0F586

Q34200930-34089453-F615-4E4D-A282-AD4B7F395796

Q34200930-3CA1AEE9-D5B4-4EC3-A397-2D815D494F1F

Q34200930-41FC152C-B8E3-4964-8DFD-1FF8520D17A3

P304

Q34200930-D1D7CE79-B807-48FC-9B73-4A43DD12EDDC

P31

Q34200930-C260A990-E368-4FD8-90FE-E4DAF286B0D2

P356

Q34200930-618B0122-B1F1-4352-9975-A360828D325E

P407

Q34200930-68327EFE-2743-4CBB-851E-DE635931ED9E

P433

Q34200930-28B6C66F-979B-49AD-BC17-C55B27AB229A

P478

Q34200930-A34CF4BE-598E-4699-9658-DE82FAFA68FC

P50

Q34200930-252D3429-708F-45D8-9400-AD8DAD4F8E4C

Q34200930-5BBD8CDE-AE5E-4927-9337-5F99CE4EAD53

Q34200930-A888406C-8A90-45DF-B85D-5276E78877A7

Q34200930-D16051A6-152F-427C-83EF-975F07BA1BC7

Q34200930-FCE5AE8B-28EE-41AC-A745-BC340A49D294

P577

Q34200930-3272A7A5-C94B-4943-BC24-616726B62E1D

P5875

Q34200930-A73A83ED-272D-4451-820D-7E4D42FA6918

P698

Q34200930-FF51B234-5E6E-46F1-AB6B-6E94C11AB52D

P921

Q34200930-66CD8EA1-18B2-45F4-A26F-DCE1F75BB641

P932

Q34200930-06B061DE-CAFB-4C6F-BA4F-81137A3D8973

P356

JOURNAL.PONE.0033418

P1433

P1476

Targeting the lactate transpor ...... vation and tumor angiogenesis.

@en

P2093

Anthony Ribeiro

http://www.w3.org/2001/XMLSchema#string

Bernard Gallez

http://www.w3.org/2001/XMLSchema#string

Christophe J De Saedeleer

http://www.w3.org/2001/XMLSchema#string

Eui Jung Moon

http://www.w3.org/2001/XMLSchema#string

Françoise Frérart

http://www.w3.org/2001/XMLSchema#string

Julien Verrax

http://www.w3.org/2001/XMLSchema#string

Kelly M Kennedy

http://www.w3.org/2001/XMLSchema#string

Mark W Dewhirst

http://www.w3.org/2001/XMLSchema#string

Olivier Feron

http://www.w3.org/2001/XMLSchema#string

Tamara Copetti

http://www.w3.org/2001/XMLSchema#string

P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Hallmarks of Cancer: The Next Generation

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Understanding the Warburg effect: the metabolic requirements of cell proliferation

HIF-1: upstream and downstream of cancer metabolism

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Mouse aortic ring assay: A new approach of the molecular genetics of angiogenesis

P304

e33418

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0033418

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Carine Michiels

Pierre Sonveaux

Frédérique Végran

P577

2012-03-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221716458

http://www.w3.org/2001/XMLSchema#string

P698

22428047

http://www.w3.org/2001/XMLSchema#string

P921

P932

3302812

http://www.w3.org/2001/XMLSchema#string