Overexpression of Gs alpha protein in the hearts of transgenic mice
about
Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cellsCritical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposureViral-mediated gene delivery of constitutively activated G alpha s alters vasoreactivityTargeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivityPKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signalingProgressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.Protective Role for LPA3 in Cardiac Hypertrophy Induced by Myocardial Infarction but Not by Isoproterenol.GNAS gene variants affect β-blocker-related survival after coronary artery bypass grafting.Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouseFibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.Alternate protein kinase A activity identifies a unique population of stromal cells in adult boneTargeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.Preserved cardiac function despite marked impairment of cAMP generation.Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytesRegulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.Cardiac GPCRs: GPCR signaling in healthy and failing hearts.Cardiac Effects of Attenuating Gsα - Dependent SignalingCardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway.Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flightMitochondria in cardiac hypertrophy and heart failure.An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling.Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.Differential regulation of inotropy and lusitropy in overexpressed Gsalpha myocytes through cAMP and Ca2+ channel pathways.Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.Targeted expression of activated Q227L G(alpha)(s) in vivo.Overexpression of G(s)alpha in NG108-15, neuroblastomaXglioma cells: effects on receptor regulation of the stimulatory adenylyl cyclase cascade.Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes.Modulation of L-type Ca2+ channels in neonatal rat heart by a novel Ca2+ channel agonist.Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure.Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism.Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors.Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes.
P2860
Q24529943-9019BA3C-27F6-4B34-8E80-3405B04C4880Q24811167-A30E81EC-84A4-42E4-A1FE-60EA6A2DD597Q28371952-42EB6CF6-72EC-48A4-BDE9-1A29F0EA7220Q28506805-9C055B12-C3B4-4E90-B672-9B87A7F10DFAQ30408840-D3804782-72FE-4DE5-A7CB-82AC2663E064Q33724552-22FF0C30-AA37-4AE9-9330-743DDBCD44C9Q33736651-795C6BF9-1764-4901-B16E-6B1D75BEBFFAQ33803705-42730C04-163F-4FB3-9260-0D6DF7EFE436Q33858191-33B45883-0F99-4329-AFDC-3D5BF00612B4Q33916995-3ABB91E1-70BB-498F-B167-AE6A4B8BD43DQ33928427-05915D5D-21EA-45D0-A2DD-03981245ADCFQ34519352-EB4ABC02-433C-4306-9439-DA83C32E9076Q34700987-230B8FC3-894D-4115-A385-FEEA9D229DE7Q35023632-68A1519C-5109-4B21-B214-424BCB802F7EQ35559287-7F354FA4-A038-4C1E-A896-24592684A3B2Q35785891-7965C150-C00C-4C1D-AE5E-8361D4B7D924Q35787715-8D0FFFD9-9C61-41ED-ACB0-A082A32C43B6Q35842857-86A3ED71-DEC1-4B42-A576-585DAD1BBBA2Q35904773-B339D555-A76E-4639-B22D-C2FE29FAA744Q36273572-BEA60EFC-7BA8-4771-A0B1-AE0FDB324E90Q36808207-A4EE5687-3E2A-4B46-A0EA-7BA4412B7E56Q37246892-9F504DBD-8A3D-407B-B5AD-9DA5D04C7F7AQ37271880-2396A35E-C8EE-4867-9983-0226C44E08F2Q37381474-185B684C-85D1-4A64-816A-07DFAA19B41BQ37413257-C3277A9D-78F4-4FDC-97F6-9077143E01C9Q38173671-6A049E02-6F4D-4E29-B833-FCFFA51F96ADQ38353052-DEC2732E-5610-40D4-A3D3-556255FA9FDCQ39828113-BCF85007-B31B-4DAA-8AD5-F921B4A1B0F0Q40850426-952829CE-1468-4C4F-BB5B-FD3A10E8ACA2Q42060564-2986BF51-16DE-4343-A62F-A901836C3871Q42068044-E7F638C7-A64F-468F-B304-9DF04293621AQ42182103-3AB38393-2FD7-48DE-BC23-FC497BCAE986Q42523424-DECEB8D3-1DF7-451D-9C33-FF94119AECF2Q42527869-CE2C8C41-BEE0-44A5-B281-693D908DC1FDQ42822434-36ECE552-00F0-4BAA-B6B4-591E7E79296BQ44413505-16051CDA-CB70-4ABC-B45C-C52CF0F60ECDQ44764142-906D2DEC-159B-4725-9EA0-C6260749D80CQ45712875-E42A5DC1-6562-42DA-8279-91F07B6DCAB7Q45883674-D0C11F18-0FE2-4C96-A629-076ECA6C2979Q51043301-978EE177-FE71-415B-9843-A58B84B228B2
P2860
Overexpression of Gs alpha protein in the hearts of transgenic mice
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Overexpression of Gs alpha protein in the hearts of transgenic mice
@ast
Overexpression of Gs alpha protein in the hearts of transgenic mice
@en
Overexpression of Gs alpha protein in the hearts of transgenic mice
@nl
type
label
Overexpression of Gs alpha protein in the hearts of transgenic mice
@ast
Overexpression of Gs alpha protein in the hearts of transgenic mice
@en
Overexpression of Gs alpha protein in the hearts of transgenic mice
@nl
prefLabel
Overexpression of Gs alpha protein in the hearts of transgenic mice
@ast
Overexpression of Gs alpha protein in the hearts of transgenic mice
@en
Overexpression of Gs alpha protein in the hearts of transgenic mice
@nl
P2093
P2860
P356
P1476
Overexpression of Gs alpha protein in the hearts of transgenic mice
@en
P2093
B Nadal-Ginard
D E Vatner
T E Wagner
Y Ishikawa
P2860
P304
P356
10.1172/JCI117843
P407
P577
1995-04-01T00:00:00Z