Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.
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Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic toolTargeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.Real time visualization of agonist-mediated redistribution and internalization of a green fluorescent protein-tagged form of the thyrotropin-releasing hormone receptor.Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System.Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation.Comparative analysis of high-affinity ligand binding and G protein coupling of the human CXCR1 chemokine receptor and of a CXCR1-Galpha fusion protein after heterologous production in baculovirus-infected insect cells.2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.Kinetic analysis of M2 muscarinic receptor activation of Gi in Sf9 insect cell membranes.The olfactory G protein G(alphaolf) possesses a lower GDP-affinity and deactivates more rapidly than G(salphashort): consequences for receptor-coupling and adenylyl cyclase activation.Delineation of the structural basis for the activation properties of the dopamine D1 receptor subtypes.Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).High constitutive activity of the human formyl peptide receptor.Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding.Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein.GDP affinity and order state of the catalytic site are critical for function of xanthine nucleotide-selective Galphas proteins.Distinct interactions of GTP, UTP, and CTP with G(s) proteins.Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3).Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s).Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants.Maturation of rat brain is accompanied by differential expression of the long and short splice variants of G(s)alpha protein: identification of cytosolic forms of G(s)alpha.Promiscuous coupling at receptor-Galpha fusion proteins. The receptor of one covalent complex interacts with the alpha-subunit of another.Coupling efficacy and selectivity of the human mu-opioid receptor expressed as receptor-Galpha fusion proteins in Escherichia coli.Properties of Arg389-beta1-adrenoceptor-Gsalpha fusion proteins: comparison with Gly389-beta1-adrenoceptor-Gsalpha fusion proteins.N (α)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study.A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.Activating mutations of GNAS in canine cortisol-secreting adrenocortical tumors.The state of GPCR research in 2004.
P2860
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P2860
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Different effects of Gsalpha s ...... onstitutively active receptor.
@en
Different effects of Gsalpha s ...... onstitutively active receptor.
@nl
type
label
Different effects of Gsalpha s ...... onstitutively active receptor.
@en
Different effects of Gsalpha s ...... onstitutively active receptor.
@nl
prefLabel
Different effects of Gsalpha s ...... onstitutively active receptor.
@en
Different effects of Gsalpha s ...... onstitutively active receptor.
@nl
P2093
P2860
P356
P1476
Different effects of Gsalpha s ...... onstitutively active receptor.
@en
P2093
Kobilka BK
Sanders-Bush E
Wenzel-Seifert K
P2860
P304
P356
10.1074/JBC.273.9.5109
P407
P577
1998-05-01T00:00:00Z