Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity - Wikidata - wikimedia - TriplyDB

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

http://www.wikidata.org/entity/Q34210006

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Oxidative Stress Signaling in Alzheimers Disease Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Alzheimer mechanisms and therapeutic strategies Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons APOE genotype and stress response - a mini review Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Oxidized cholesterol as the driving force behind the development of Alzheimer's disease Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer's disease.Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology Pathogenesis of Alzheimer's disease GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors Prediction of the functional class of metal-binding proteins from sequence derived physicochemical properties by support vector machine approach Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients.Genetic variation at a single locus and age of onset for Alzheimer's disease.The Alzheimer's disease mitochondrial cascade hypothesis Association of hypometabolism and amyloid levels in aging, normal subjects An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42 APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease A mitochondrial etiology of Alzheimer and Parkinson disease Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.Characterizing the preclinical stages of Alzheimer's disease and the prospect of presymptomatic intervention.Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice Apolipoprotein E: from lipid transport to neurobiology The role of apolipoprotein E in Alzheimer's disease.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms.Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex.

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P2860

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

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2005 nî lūn-bûn

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2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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Lipid- and receptor-binding re ...... dysfunction and neurotoxicity

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Lipid- and receptor-binding re ...... dysfunction and neurotoxicity

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Lipid- and receptor-binding re ...... dysfunction and neurotoxicity

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Lipid- and receptor-binding re ...... dysfunction and neurotoxicity

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Lipid- and receptor-binding re ...... dysfunction and neurotoxicity

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Maureen E Balestra

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R Dennis Miranda

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Robert W Mahley

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Shengjun Chang

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Tian ran Ma

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Yadong Huang

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Apolipoprotein E: far more than a lipid transport protein

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

Mitochondrial ALDH2 deficiency as an oxidative stress

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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