DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle - Wikidata - wikimedia - TriplyDB

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

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Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD)Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation Influence of Repressive Histone and DNA Methylation upon D4Z4 Transcription in Non-Myogenic Cells Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways Facioscapulohumeral Dystrophy.β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy.Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation DUX4 promotes transcription of FRG2 by directly activating its promoter in facioscapulohumeral muscular dystrophy Meeting Report: New Directions in the Biology and Disease of Skeletal Muscle 2014 Muscle pathology grade for facioscapulohumeral muscular dystrophy biopsies.Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD Large family cohorts of lymphoblastoid cells provide a new cellular model for investigating facioscapulohumeral muscular dystrophy.DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy DNA-binding sequence specificity of DUX4.Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy.Skeletal Muscle MicroRNAs: Their Diagnostic and Therapeutic Potential in Human Muscle Diseases.Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.PARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD).Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophy.Loss of epigenetic silencing of the DUX4 transcription factor gene in facioscapulohumeral muscular dystrophy.p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles.Direct interplay between two candidate genes in FSHD muscular dystrophy.Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.Emerging roles of macrosatellite repeats in genome organization and disease development.SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells.The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation.Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.Dux4 controls migration of mesenchymal stem cells through the Cxcr4-Sdf1 axis.PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle.A recessive mutation in beta-IV-spectrin (SPTBN4) associates with congenital myopathy, neuropathy, and central deafness.Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.Antisense targeting of 3' end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for facioscapulohumeral dystrophy: a new gene-silencing approach.Facioscapulohumeral Muscular Dystrophy.Monosomy 18p is a risk factor for facioscapulohumeral dystrophy.NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.

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DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

http://www.wikidata.org/entity/Q34211798

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@ast

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@en

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

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type

label

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@ast

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@en

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

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prefLabel

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@ast

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

@en

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

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Human Molecular Genetics

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DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

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Judit Balog

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Lauren Snider

http://www.w3.org/2001/XMLSchema#string

Rabi Tawil

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Richard J L F Lemmers

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Stephen J Tapscott

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Zizhen Yao

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P2860

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

Facioscapulohumeral muscular dystrophy: consequences of chromatin relaxation

Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy

Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis

Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1

A unifying genetic model for facioscapulohumeral muscular dystrophy

Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes

Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.

Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation.

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5342-5352

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10.1093/HMG/DDU251

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20

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23

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Silvère M van der Maarel

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2014-05-26T00:00:00Z

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262646021

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24861551

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4168822

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