Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
about
Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury.Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple SclerosisNeuronal gap junctions: making and breaking connections during development and injuryDisruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edemaBiphasic mechanisms of neurovascular unit injury and protection in CNS diseasesNovel NMDA receptor modulators: an updatePharmacologic neuroprotective strategies in neonatal brain injuryNeuroprotection for stroke: current status and future perspectivesThe NMDA receptor complex: a multifunctional machine at the glutamatergic synapseCurrent approaches to enhance glutamate transporter function and expressionThe transcriptome of cerebral ischemiaThe fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015Guanosine: a Neuromodulator with Therapeutic Potential in Brain DisordersTraumatic brain injury and NADPH oxidase: a deep relationshipEmerging therapies in traumatic brain injuryMolecular mechanisms in the pathogenesis and treatment of acute ischemic strokeTherapeutic use of PDZ protein-protein interaction antagonismGlutamate receptor ion channels: structure, regulation, and functionDevelopment of NMDAR antagonists with reduced neurotoxic side effects: a study on GK11TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic strokeAcacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in ratsTargeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of strokeThe far-reaching scope of neuroinflammation after traumatic brain injury.TRPM7 and ischemic CNS injury.Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptorsNormobaric hyperoxia therapy for traumatic brain injury and stroke: a review.Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impactValidation of serum markers for blood-brain barrier disruption in traumatic brain injury.To look beyond vasospasm in aneurysmal subarachnoid haemorrhage.Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels.Mechanisms of neurovascular dysfunction in acute ischemic brain.Restoring neuroprotection through a new preclinical paradigm: translational success for NA-1 in stroke therapyThe ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors.Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin.Small chaperons and autophagy protected neurons from necrotic cell deathAcid-sensing ion channels in acidosis-induced injury of human brain neuronsThe effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia.Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Activation of NR2A receptors induces ischemic tolerance through CREB signaling.Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats.
P2860
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P2860
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@ast
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@en
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@nl
type
label
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@ast
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@en
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@nl
prefLabel
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@ast
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@en
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@nl
P1433
P1476
Why did NMDA receptor antagoni ...... ke and traumatic brain injury?
@en
P2093
Chrysanthy Ikonomidou
Lechoslaw Turski
P304
P356
10.1016/S1474-4422(02)00164-3
P577
2002-10-01T00:00:00Z