Acid-sensing ion channels in acidosis-induced injury of human brain neurons
about
Ionic regulation of cell volume changes and cell death after ischemic stroke.Physiological and pathological functions of acid-sensing ion channels in the central nervous system.Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs.Acid-sensing ion channels: trafficking and synaptic function.Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion.Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosisExpression and activity of acid-sensing ion channels in the mouse anterior pituitary.Acid-sensing ion channels: potential therapeutic targets for neurologic diseases.Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.Acid-sensing ion channels under hypoxia.Acid-sensing ion channels contribute to neurotoxicity.Spider venomics: implications for drug discovery.Regulating Factors in Acid-Sensing Ion Channel 1a Function.ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway.Acid Sensing Ion Channels (ASICs) in NS20Y cells - potential role in neuronal differentiation.Fluorescence-Based Automated Screening Assay for the Study of the pH-Sensitive Channel ASIC1a.Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion.Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cells.The role of ASICS in cerebral ischemia.Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.Computational elucidation, Mutational and Hot spot-based designing of potential inhibitors against human acid-sensing ion channels (hASIC-1a) to treatment of various physiological conditions.pH-sensitive MRI demarcates graded tissue acidification during acute stroke - pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI.Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation.High doses of salicylate and aspirin are inhibitory on acid-sensing ion channels and protective against acidosis-induced neuronal injury in the rat cortical neuron.Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases.
P2860
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P2860
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@ast
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@en
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@nl
type
label
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@ast
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@en
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@nl
prefLabel
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@ast
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@en
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@nl
P2093
P2860
P356
P1476
Acid-sensing ion channels in acidosis-induced injury of human brain neurons
@en
P2093
Deborah Branigan
Eric Kratzer
Jeff W Chen
Jillian C Hansen
Koichi Inoue
Minghua Li
Roger P Simon
Zhi-Gang Xiong
P2860
P304
P356
10.1038/JCBFM.2010.30
P577
2010-03-10T00:00:00Z