Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.
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Dynorphin--still an extraordinarily potent opioid peptideDiscovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonistsPET Neurochemical Imaging Modes.Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects.An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989.Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.PET imaging reveals sex differences in kappa opioid receptor availability in humans, in vivoKinetic modeling of (11)C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans.Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors.Semisynthetic neoclerodanes as kappa opioid receptor probes.Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors.Development of κ opioid receptor antagonists.The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety testsSynthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imagingThe discovery and development of the N-substituted trans-3,4-dimethyl-4-(3'-hydroxyphenyl)piperidine class of pure opioid receptor antagonists.Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.Enantioselective amine α-functionalization via palladium-catalysed C-H arylation of thioamides.Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human."Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats".Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates.Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding.In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145.PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
P2860
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P2860
Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@ast
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@en
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@nl
type
label
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@ast
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@en
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@nl
prefLabel
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@ast
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@en
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@nl
P2093
P356
P1476
Discovery of aminobenzyloxyary ...... ist receptor occupancy tracer.
@en
P2093
Alma Jimenez
Charles H Mitch
Concepcion Pedregal
Dana R Benesh
David L McKinzie
Emily J Canada
Karen S Rash
Marta G de la Torre
Michael A Statnick
Nuria Diaz
P304
P356
10.1021/JM200789R
P407
P50
P577
2011-10-26T00:00:00Z