A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disordersSynthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsCentrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsAllosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatmentDiscovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyAllosteric modulation of metabotropic glutamate receptors.Targeting glutamate synapses in schizophreniaDiscovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsPreferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors.Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesSynthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.mGluR7's lucky number.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationPositive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.Glutamatergic targets for enhancing extinction learning in drug addictionHeptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co-expressed on rat and human noradrenergic terminalsMolecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings.Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsmGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.
P2860
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P2860
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A family of highly selective a ...... glutamate receptor subtype 5.
@ast
A family of highly selective a ...... glutamate receptor subtype 5.
@en
A family of highly selective a ...... glutamate receptor subtype 5.
@nl
type
label
A family of highly selective a ...... glutamate receptor subtype 5.
@ast
A family of highly selective a ...... glutamate receptor subtype 5.
@en
A family of highly selective a ...... glutamate receptor subtype 5.
@nl
prefLabel
A family of highly selective a ...... glutamate receptor subtype 5.
@ast
A family of highly selective a ...... glutamate receptor subtype 5.
@en
A family of highly selective a ...... glutamate receptor subtype 5.
@nl
P2093
P356
P1476
A family of highly selective a ...... glutamate receptor subtype 5.
@en
P2093
Cyrille Sur
David L Williams
Douglas J Pettibone
Hervé J Schaffhauser
Julie A O'Brien
Marlene A Jacobson
Raymond S L Chang
Sookhee N Ha
Tsing-Bau Chen
Wei Lemaire
P304
P356
10.1124/MOL.64.3.731
P577
2003-09-01T00:00:00Z