Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
about
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsDiscovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingVU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyExploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinUnique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Critical design issues in the targeted molecular imaging of cell surface receptors.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryA novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signalingDesign of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.Allosteric modulation and functional selectivity of G protein-coupled receptors.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksDihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptorIdentification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.The mGluR5 positive allosteric modulator CDPPB inhibits SO₂-induced protein radical formation and mitochondrial dysfunction through activation of Akt in mouse hippocampal HT22 cells.2-[2-(4-Methyl-piperazin-1-yl)eth-yl]iso-indoline-1,3-dione.Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyComparative in vitro studies of MR imaging probes for metabotropic glutamate subtype-5 receptor targeting.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild TypeDiscovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions.
P2860
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P2860
Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
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name
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@ast
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@en
type
label
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@ast
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@en
prefLabel
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@ast
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@en
P2860
P356
P1476
Progress toward positive allos ...... e receptor subtype 5 (mGluR5).
@en
P2093
Shaun R Stauffer
P2860
P304
P356
10.1021/CN2000519
P577
2011-06-27T00:00:00Z