WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. - Wikidata - wikimedia - TriplyDB

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

http://www.wikidata.org/entity/Q34224821

about

The spectrum of WRN mutations in Werner syndrome patients Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes Human premature aging, DNA repair and RecQ helicases Disease-causing missense mutations in human DNA helicase disorders The role of RecQ helicases in non-homologous end-joining Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity WRN regulates pathway choice between classical and alternative non-homologous end joining The role of mitochondrial DNA mutations in mammalian aging A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging.WRN participates in translesion synthesis pathway through interaction with NBS1 DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells Junction of RecQ helicase biochemistry and human disease.Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.Helicase-inactivating mutations as a basis for dominant negative phenotypes.Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.DNA helicases involved in DNA repair and their roles in cancer DNA helicases associated with genetic instability, cancer, and aging.Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability Human RecQ helicases in DNA repair, recombination, and replication.Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability RECQ helicases are deregulated in hematological malignancies in association with a prognostic value Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons.Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress.Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.Targeting an Achilles' heel of cancer with a WRN helicase inhibitor Chromatin and beyond: the multitasking roles for SIRT6 Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.Non-homologous end joining: advances and frontiers.Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.Crosstalk between the nucleolus and the DNA damage response.BCR/ABL stimulates WRN to promote survival and genomic instability.

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P2860

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

http://www.wikidata.org/entity/Q34224821

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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WRN, the protein deficient in ...... role in optimizing DNA repair.

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J.1474-9728.2003.00052.X

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P1476

WRN, the protein deficient in ...... role in optimizing DNA repair.

@en

P2093

Albert Davalos

http://www.w3.org/2001/XMLSchema#string

Judith Campisi

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Junko Oshima

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Lin Lee

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Lishan Chen

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Robert H Schiestl

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Shurong Huang

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P2860

Characterization of the human and mouse WRN 3'-->5' exonuclease

Regulation and localization of the Bloom syndrome protein in response to DNA damage

p53 Modulates the exonuclease activity of Werner syndrome protein

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

Functional interaction between Ku and the werner syndrome protein in DNA end processing

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

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191-199

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10.1046/J.1474-9728.2003.00052.X

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4

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2003-08-01T00:00:00Z

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10600239

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12934712

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