Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability - Wikidata - wikimedia - TriplyDB

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

http://www.wikidata.org/entity/Q36573932

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Rothmund-Thomson syndrome Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome Roles of Werner syndrome protein in protection of genome integrity Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging Human premature aging, DNA repair and RecQ helicases Nucleases in homologous recombination as targets for cancer therapy Disease-causing missense mutations in human DNA helicase disorders Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains Structure of the human RECQ1 helicase reveals a putative strand-separation pin Molecular mimicry of SUMO promotes DNA repair Structure and function of the regulatory HRDC domain from human Bloom syndrome protein RecQ helicases in DNA double strand break repair and telomere maintenance.Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.RecQ helicases: guardian angels of the DNA replication fork.WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3 Mechanistic and biological aspects of helicase action on damaged DNA.Distinct roles of RECQ1 in the maintenance of genomic stability.Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.Delineation of WRN helicase function with EXO1 in the replicational stress response Molecular analyses of DNA helicases involved in the replicational stress response.CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.DNA repair deficiency in neurodegeneration.Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.The mutation spectrum in RECQL4 diseases.The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing.Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Impact of age-associated cyclopurine lesions on DNA repair helicases.Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism

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Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

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Mechanisms of RecQ helicases i ...... intenance of genomic stability

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Kevin M Doherty

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Robert M Brosh

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Functional and physical interaction between WRN helicase and human replication protein A

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

Ku complex interacts with and stimulates the Werner protein

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

Characterization of the human and mouse WRN 3'-->5' exonuclease

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

Regulation and localization of the Bloom syndrome protein in response to DNA damage

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

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319-337

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10.1042/BJ20060450

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