Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.
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The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a reviewTranscriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalizationGagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivoRecombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus MacaquesTherapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaquesCo-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cellsHIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development.The development of an AIDS mucosal vaccine.Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequencesHIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers.Epithelial stem cells as mucosal antigen-delivering cells: A novel AIDS vaccine approach.Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hostsDNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.Is an HIV vaccine possible?Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay.Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challengeAttenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing GagCytotoxic T-lymphocyte escape does not always explain the transient control of simian immunodeficiency virus SIVmac239 viremia in adenovirus-boosted and DNA-primed Mamu-A*01-positive rhesus macaquesElicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40LmNon-human primate models for AIDS vaccine research.Simian immunodeficiency virus SIVmac239Deltanef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques.Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.Non-equilibrium and differential function between intraepithelial and lamina propria virus-specific TCRalphabeta(+) CD8alphabeta(+) T cells in the small intestinal mucosa.Pyrosequencing reveals restricted patterns of CD8+ T cell escape-associated compensatory mutations in simian immunodeficiency virus.Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replicationVaccinia Virus LC16m8∆ as a Vaccine Vector for Clinical Applications.Induction of mucosal HIV-specific B and T cell responses after oral immunization with live coxsackievirus B4 recombinantsBasic statistical considerations in virological experiments.Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques.HIV vaccine design: insights from live attenuated SIV vaccines.Intranasal delivery of vaccines against HIV.Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery.Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.Problems and emerging approaches in HIV/AIDS vaccine development.Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans.Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaques.Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing the simian immunodeficiency virus Gag/Tat fusion protein and challenged intrarectally with repeated low doses of SIVmac.
P2860
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P2860
Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@ast
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@en
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@nl
type
label
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@ast
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@en
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@nl
prefLabel
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@ast
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@en
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@nl
P2093
P2860
P50
P1433
P1476
Multispecific vaccine-induced ...... unodeficiency virus SIVmac239.
@en
P2093
Chenxi Wang
James T Fuller
John D Altman
Kathy Vielhuber
Kevin J Kunstman
Marta L Marthas
Matthew R Reynolds
Nancy Wilson
Thorsten U Vogel
Tim Shipley
P2860
P304
13348-13360
P356
10.1128/JVI.77.24.13348-13360.2003
P407
P50
P577
2003-12-01T00:00:00Z