With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.
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Challenges in mucosal HIV vaccine development: lessons from non-human primate modelsCharacterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profilingCD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protectionHigh avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral functionAdhesion Molecules Associated with Female Genital Tract InfectionTherapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaquesRole of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV VaccineLocalized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epitheliumDepo-provera treatment does not abrogate protection from intravenous SIV challenge in female macaques immunized with an attenuated AIDS virus.Use of nonhuman primate models to develop mucosal AIDS vaccines.Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication.Memory B cells and CD8⁺ lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques.Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques.CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.Viral RNA levels and env variants in semen and tissues of mature male rhesus macaques infected with SIV by penile inoculation.Comparison of Vibratome and Compresstome sectioning of fresh primate lymphoid and genital tissues for in situ MHC-tetramer and immunofluorescence staining.Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.Characterization of an effective CTL response against HIV and SIV infections.Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.Durable mucosal simian immunodeficiency virus-specific effector memory T lymphocyte responses elicited by recombinant adenovirus vectors in rhesus monkeysLow-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaIn Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8+ T cells--A Tool to Interrogate a Functional Immune Response Ex Vivo.Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6.Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.Antiviral antibodies and T cells are present in the foreskin of simian immunodeficiency virus-infected rhesus macaques.Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques.Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimensLimited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirusImproved outlook on HIV-1 prevention and vaccine development.Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases.High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques.Exploiting the natural history of cytomegalovirus to vaccinate against HIV.
P2860
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P2860
With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
With minimal systemic T-cell e ...... simian immunodeficiency virus.
@en
type
label
With minimal systemic T-cell e ...... simian immunodeficiency virus.
@en
prefLabel
With minimal systemic T-cell e ...... simian immunodeficiency virus.
@en
P2093
P2860
P356
P1433
P1476
With minimal systemic T-cell e ...... simian immunodeficiency virus
@en
P2093
Christopher J Miller
Jung Joo Hong
Michael B McChesney
P2860
P304
11181-11196
P356
10.1128/JVI.01433-08
P407
P577
2008-09-10T00:00:00Z