Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
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1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an EnigmaSphingolipid signaling in metabolic disordersIdentification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1.HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.Sphingolipid metabolites in inflammatory disease.Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificityPlasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitusThe debut of a rational treatment for an inherited neuropathy?Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root GangliaGender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathyMetabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP)Antioxidant and cytoprotective effects of L-Serine on human endothelial cells.Solving the riddle of the sphinx may provide new insights into diabetes and polyneuropathy.Mutations at Ser331 in the HSN type I gene SPTLC1 are associated with a distinct syndromic phenotypePlasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet.Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia.Inherited neuropathies: clinical overview and update.Deoxysphingolipids: β-cell, beware of these new kids on the block.Traditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for NeuroprotectionA world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose.Structural, mechanistic and regulatory studies of serine palmitoyltransferase.Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.Clinical implications of genetic advances in Charcot-Marie-Tooth disease.Progress in peripheral nerve disease research in the last two years.Human genetic disorders of sphingolipid biosynthesis.The consequences of genetic and pharmacologic reduction in sphingolipid synthesis.The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview.Painless Ulcers and Fissures of Toes: Hereditary Sensory Neuropathy, Not Leprosy.Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?Target-enrichment sequencing and copy number evaluation in inherited polyneuropathy.Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of L-Serine.The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy.De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease.The Charcot-Marie-Tooth diseases: how can we identify and develop novel therapeutic targets?The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutationsGenomic disorders 20 years on-mechanisms for clinical manifestations.Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction.Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study.Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C.
P2860
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P2860
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@ast
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@en
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@nl
type
label
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@ast
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@en
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@nl
prefLabel
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@ast
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@en
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@nl
P2093
P2860
P356
P1476
Oral L-serine supplementation ...... autonomic neuropathy type 1.
@en
P2093
Anke Penno
Brian P Schmidt
Florian S Eichler
Ho-Joon Lee
Kevin Garofalo
Matthew P Frosch
Robert H Brown
Thorsten Hornemann
P2860
P304
P356
10.1172/JCI57549
P407
P577
2011-12-01T00:00:00Z