Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.
about
A hostel for the hostile: the bone marrow niche in hematologic neoplasmsAssociation of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cellsBCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cellsVLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cellsStructural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events.Recent advances in the molecular and cellular biology of chronic myeloid leukaemia: lessons to be learned from the laboratory.Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells.Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins.Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML.Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferationTreatment of marrow stroma with interferon-alpha restores normal beta 1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1 alpha.Evolving molecular therapy for chronic myeloid leukaemia--are we on target?An in vitro model for cytogenetic conversion in CML. Interferon-alpha preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture.Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activityMobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function.Beta 1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction.Myeloid malignancies and the microenvironment.BCR/ABL induces multiple abnormalities of cytoskeletal function.Treatment with interferon-alpha preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM.Pegylated interferon for the treatment of early myelofibrosis: correlation of serial laboratory studies with response to therapy.Interaction of the seed and the soil.Interferon-alpha and bcr-abl antisense oligodeoxynucleotides in combination enhance the antileukemic effect and the adherence of CML progenitors to preformed stroma.Functional analysis of a single chain chimeric alpha/beta-granulocyte-macrophage colony-stimulating factor receptor. Importance of a glutamate residue in the transmembrane region.Influence of interferon-alpha on cytokine expression by the bone marrow microenvironment--impact on treatment of myeloproliferative disorders.The role of autologous natural killer cells in chronic myelogenous leukemia.The effect of interferon-alpha on beta-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia.L-selectin expression in CD34 positive cells in chronic myeloid leukemia.Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells.Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors.The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells.Imatinib restores expression of CD62L in BCR-ABL-positive cells.Blast colony-forming cell binding from CML bone marrow, or blood, on stromal layers pretreated with G-CSF or SCF.Mathematical modeling of genesis and treatment of chronic myeloid leukemia.Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia
P2860
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P2860
Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Interferon-alpha restores norm ...... 1 integrin receptor function.
@ast
Interferon-alpha restores norm ...... 1 integrin receptor function.
@en
Interferon-alpha restores norm ...... 1 integrin receptor function.
@nl
type
label
Interferon-alpha restores norm ...... 1 integrin receptor function.
@ast
Interferon-alpha restores norm ...... 1 integrin receptor function.
@en
Interferon-alpha restores norm ...... 1 integrin receptor function.
@nl
prefLabel
Interferon-alpha restores norm ...... 1 integrin receptor function.
@ast
Interferon-alpha restores norm ...... 1 integrin receptor function.
@en
Interferon-alpha restores norm ...... 1 integrin receptor function.
@nl
P2093
P2860
P356
P1476
Interferon-alpha restores norm ...... 1 integrin receptor function.
@en
P2093
C M Verfaillie
E A Wayner
P B McGlave
P2860
P304
P356
10.1172/JCI117333
P407
P577
1994-07-01T00:00:00Z