Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. - Wikidata - wikimedia - TriplyDB

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

http://www.wikidata.org/entity/Q34245120

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Adult Stem Cell Responses to Nanostimuli Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis Physiological mechanisms and therapeutic potential of bone mechanosensing.Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways Using biomaterials to study stem cell mechanotransduction, growth and differentiation The primary cilium functions as a mechanical and calcium signaling nexus Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts.Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway.Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.Development of a method for the measurement of primary cilia length in 3D.Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.The effect of compressive loading magnitude on in situ chondrocyte calcium signaling.Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1.Mechanobiology of Ciliogenesis.Mechanobiology of TGFβ signaling in the skeleton.Mechanical regulation of chondrogenesis.NFATc1 and NFATc2 repress spontaneous osteoarthritis.Purinergic signalling in the musculoskeletal system.Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients.The primary cilium as a novel extracellular sensor in bone The extracellular matrix and ciliary signaling Continuous passive motion following cartilage surgery: does a common protocol exist?Dynamic 3D culture: models of chondrogenesis and endochondral ossification.Physicochemical and biomechanical stimuli in cell-based articular cartilage repair.IFT88 influences chondrocyte actin organization and biomechanics.Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration.Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.Cell-based tissue engineering strategies used in the clinical repair of articular cartilage Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo Calcium channels in primary cilia.Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk.The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium.The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.

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Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

http://www.wikidata.org/entity/Q34245120

description

2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012 թվականի հունվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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Primary cilia mediate mechanot ...... ng in compressed chondrocytes.

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Primary cilia mediate mechanot ...... ng in compressed chondrocytes.

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Primary cilia mediate mechanot ...... ing in compressed chondrocytes

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P2093

Angus K T Wann

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C Anthony Poole

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Courtney J Haycraft

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Cynthia G Jensen

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Ning Zuo

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Susan R McGlashan

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P2860

Localization of extracellular matrix receptors on the chondrocyte primary cilium

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Loss of the Tg737 protein results in skeletal patterning defects

Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination

Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice.

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1663-1671

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scholarly article

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10.1096/FJ.11-193649

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4

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26

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Martin M Knight

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2012-01-05T00:00:00Z

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221728052

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22223751

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Mechanotransduction

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3316893

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