Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia
about
Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytesKnowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysisLarge granular lymphocytic leukemia. Current diagnostic and therapeutic approaches and novel treatment options.Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.IL-15: a central regulator of celiac disease immunopathology.NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppressionCeliac disease: risk assessment, diagnosis, and monitoring.Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemiaInterleukin-2 activity can be fine tuned with engineered receptor signaling clamps.The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL primingPhase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.Receptor-directed therapy of T-cell leukemias and lymphomas.Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity.Antibody-based therapy of leukaemia.Large granular lymphocytic leukaemia pathogenesis and management.The immunopathogenesis of celiac disease reveals possible therapies beyond the gluten-free diet.Human dendritic cells subsets as targets and vectors for therapy.Molecular pathways: interleukin-15 signaling in health and in cancer.The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytesTargeting IL-15 in large granular lymphocyte leukemia.Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.Regulatory effects of IL-15 on allergen-induced airway obstruction.
P2860
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P2860
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@ast
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@en
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@nl
type
label
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@ast
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@en
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@nl
prefLabel
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@ast
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@en
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@nl
P2093
P2860
P921
P356
P1476
Preclinical and phase I clinic ...... e granular lymphocyte leukemia
@en
P2093
Bonita Bryant
Carolyn K Goldman
Cathryn C Lee
Jeffrey D White
John C Morris
John E Janik
Margaret Brown
Michael Petrus
Mitsuru Tsudo
P2860
P304
P356
10.1073/PNAS.0509575103
P407
P577
2005-12-30T00:00:00Z