Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelThe N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel DeactivationThe S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingMolecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelDouble mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel.Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channelsPerspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.HERG potassium channel regulation by the N-terminal eag domain.Voltage-dependent gating of HERG potassium channels.Mechanism of electromechanical coupling in voltage-gated potassium channels.Getting to the heart of hERG K(+) channel gating.NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels.Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow DeactivationA new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.Sequence of gating charge movement and pore gating in HERG activation and deactivation pathwaysMolecular determinants of U-type inactivation in Kv2.1 channels.A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization.External protons destabilize the activated voltage sensor in hERG channels.Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains.The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels.Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.The solution structure of the S4-S5 linker of the hERG potassium channel
P2860
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P2860
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
description
2010 nî lūn-bûn
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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@ast
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@en
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@nl
type
label
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@ast
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@en
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@nl
prefLabel
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@ast
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@en
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@nl
P2093
P2860
P1433
P1476
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
@en
P2093
Aaron C Van Slyke
Charlene R Allard
Mischa Snopkowski
Patrick Shi
Saman Rezazadeh
Tom W Claydon
P2860
P304
P356
10.1016/J.BPJ.2010.08.030
P407
P577
2010-11-01T00:00:00Z