Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
about
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagyMitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?The mitochondrial unfolded protein response—synchronizing genomesThe mitochondrial unfolded protein response in mammalian physiologyMitochondrial proteostasis in the control of aging and longevityMitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infectionSelf and nonself: how autophagy targets mitochondria and bacteriaPINK1-mediated phosphorylation of Parkin boosts Parkin activity in DrosophilaKnockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease modelLithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's diseaseMitochondrial fission, fusion, and stressdATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome cThe accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's diseaseSirT3 regulates the mitochondrial unfolded protein response.Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.Mitochondrial maintenance failure in aging and role of sexual dimorphism.p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegenerationLoss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseThe ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationThe PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivoMitochondrial Proteostatic Collapse Leads to Hypoxic Injury.Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease.Insights into mitochondrial quality control pathways and Parkinson's disease.The selectivity and specificity of autophagy in Drosophila.Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response.The Role of AMPK in Drosophila melanogaster.Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila.LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins.Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.
P2860
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P2860
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@ast
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@en
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@nl
type
label
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@ast
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@en
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@nl
prefLabel
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@ast
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@en
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@nl
P2093
P2860
P356
P1476
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
@en
P2093
D Dinsdale
I Pimenta de Castro
L M Martins
P2860
P2888
P304
P356
10.1038/CDD.2012.5
P577
2012-02-03T00:00:00Z
P5875
P6179
1030835793