Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. - Wikidata - wikimedia - TriplyDB

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

http://www.wikidata.org/entity/Q34251629

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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?The mitochondrial unfolded protein response—synchronizing genomes The mitochondrial unfolded protein response in mammalian physiology Mitochondrial proteostasis in the control of aging and longevity Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection Self and nonself: how autophagy targets mitochondria and bacteria PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model Lithium suppresses AÎ² pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease Mitochondrial fission, fusion, and stress dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease SirT3 regulates the mitochondrial unfolded protein response.Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.Mitochondrial maintenance failure in aging and role of sexual dimorphism.p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury.Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease.Insights into mitochondrial quality control pathways and Parkinson's disease.The selectivity and specificity of autophagy in Drosophila.Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response.The Role of AMPK in Drosophila melanogaster.Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila.LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins.Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

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P2860

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

http://www.wikidata.org/entity/Q34251629

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@ast

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@en

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@nl

type

label

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@ast

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@en

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@nl

prefLabel

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@ast

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@en

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

@nl

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Cell Death & Differentiation

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Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

How does parkin ligate ubiquitin to Parkinson's disease?

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Unfolded protein response in a Drosophila model for retinal degeneration

Widespread protein aggregation as an inherent part of aging in C. elegans

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

The roles of intracellular protein-degradation pathways in neurodegeneration

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Drosophila melanogaster

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