Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
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Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recyclingPrinciples of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in diseaseExtending the translational potential of targeting NO/cGMP-regulated pathways in the CVSNitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malariaAntiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaqueTetrahydrobiopterin in cardiovascular health and disease.Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation.Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells.Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanismsTetrahydrobiopterin improves endothelial function in cardiovascular disease: a systematic reviewEndothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction.Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.Role of oxidative stress in endothelial insulin resistance.Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approachesLiposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection.Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation.Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase couplingTetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling.Selective up-regulation of arginase-1 in coronary arteries of diabetic patients.A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerizationReactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical researchImpaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model.Tetrahydrobiopterin Protects against Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes.Immune activation and inflammation in patients with cardiovascular disease are associated with higher phenylalanine to tyrosine ratios: the ludwigshafen risk and cardiovascular health studySignaling by S-nitrosylation in the heart.Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis.Redox biomarkers in cardiovascular medicine.The eNOS signalosome and its link to endothelial dysfunction.Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.Oral BH4: a novel remedy for age-related skin microvascular impairment during heat stress or fool's elixir?Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease.The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics.
P2860
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P2860
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Systemic and vascular oxidatio ...... with coronary artery disease.
@ast
Systemic and vascular oxidatio ...... with coronary artery disease.
@en
Systemic and vascular oxidatio ...... with coronary artery disease.
@nl
type
label
Systemic and vascular oxidatio ...... with coronary artery disease.
@ast
Systemic and vascular oxidatio ...... with coronary artery disease.
@en
Systemic and vascular oxidatio ...... with coronary artery disease.
@nl
prefLabel
Systemic and vascular oxidatio ...... with coronary artery disease.
@ast
Systemic and vascular oxidatio ...... with coronary artery disease.
@en
Systemic and vascular oxidatio ...... with coronary artery disease.
@nl
P2093
P2860
P50
P1433
P1476
Systemic and vascular oxidatio ...... with coronary artery disease.
@en
P2093
Alistair C Lindsay
Chandi Ratnatunga
Charalambos Antoniades
Cheerag Shirodaria
Colin Cunnington
Ilias Kylintireas
Justin M Lee
Marios Margaritis
Rana Sayeed
Ravi Pillai
P2860
P304
P356
10.1161/CIRCULATIONAHA.111.038919
P407
P577
2012-02-07T00:00:00Z