Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
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Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasisState of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis LungAcute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threatsMechanistic evidence in support of alpha1-antitrypsin as a therapeutic approach for type 1 diabetesNeutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway diseaseComplement System Part II: Role in ImmunityInfluence of neutrophil defects on Burkholderia cepacia complex pathogenesis.Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells.Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction.Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.Neutrophils and protease/antiprotease imbalance.RpmA is required for nonopsonic phagocytosis of Pseudomonas aeruginosa.Human monoclonal antibodies against Pseudomonas aeruginosa lipopolysaccharide derived from transgenic mice containing megabase human immunoglobulin loci are opsonic and protective against fatal pseudomonas sepsisFactors influencing airway inflammation in chronic obstructive pulmonary disease.Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumoniaModulation of secretory leukoprotease inhibitor gene expression in human bronchial epithelial cells by phorbol ester.Clinical significance of microbial infection and adaptation in cystic fibrosis.Immunization with Pseudomonas aeruginosa vaccines and adjuvant can modulate the type of inflammatory response subsequent to infection.Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes.Cystic fibrosis: new perceptions, new strategies.Nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages and polymorphonuclear leukocytes requires the presence of the bacterial flagellum.Lung infections. 3. Pseudomonas aeruginosa and other related species.Assessment of airway neutrophils by sputum colour: correlation with airways inflammation.Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients.Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition.Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of DiseaseNeutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability.Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidantsProteases and cystic fibrosis.Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs.Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis.The cystic fibrosis neutrophil: a specialized yet potentially defective cell.The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency.Host mucin glycosylation plays a role in bacterial adhesion in lungs of individuals with cystic fibrosis.Inflammation and its genesis in cystic fibrosis.Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease.
P2860
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P2860
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
description
1990 nî lūn-bûn
@nan
1990 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@ast
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@en
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@nl
type
label
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@ast
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@en
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@nl
prefLabel
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@ast
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@en
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@nl
P2093
P2860
P356
P1476
Neutrophil elastase cleaves C3 ...... ant opsonin receptor mismatch.
@en
P2093
P2860
P304
P356
10.1172/JCI114699
P407
P577
1990-07-01T00:00:00Z