Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity.
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The nature of antioxidant defense mechanisms: a lesson from transgenic studiesAerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injuryAtomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutaseParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsOxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidationMitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cellsReduced fertility in female mice lacking copper-zinc superoxide dismutaseRegulation of antioxidant enzymes in lung after oxidant injuryEffect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis.Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxiaTolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression.Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.Transgenic and knockout models for studying the role of lung antioxidant enzymes in defense against hyperoxia.Oxygen-derived species: their relation to human disease and environmental stressSOD inactivation in asthma: bad or no news?Superoxide dismutases in the lung and human lung diseases.Intracellular oxidant activity, antioxidant enzyme defense system, and cell senescence in fibroblasts with trisomy 21.Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactionsTwo functional variants of the superoxide dismutase genes in Finnish families with asthma.Alveolar cell death in hyperoxia-induced lung injury.Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory painPart of the series: from dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress.Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.An elevated level of copper zinc superoxide dismutase fails to prevent oxygen induced retinopathy in mice.Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramideTransgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.Hyperoxia sensing: from molecular mechanisms to significance in disease.Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease.Acute lung injury and pulmonary vascular permeability: use of transgenic models.Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health.Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells.Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins.Free radicals as mediators of tissue injury and disease.Antioxidant gene expression in rat lung after exposure to cigarette smoke.Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality.Use of transgenic animals to study disease models: hyperoxic lung injury and ischemic acute renal failure in "high SOD" mice.
P2860
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P2860
Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity.
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@ast
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@en
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@nl
type
label
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@ast
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@en
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@nl
prefLabel
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@ast
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@en
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@nl
P2093
P2860
P356
P1476
Transgenic mice with expressio ...... to pulmonary oxygen toxicity.
@en
P2093
K B Avraham
P F Shanley
P2860
P304
P356
10.1172/JCI115249
P407
P577
1991-06-01T00:00:00Z