Direct observation of the interconversion of normal and toxic forms of α-synuclein
about
Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopyThe chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicityDirect visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brainGut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?Mechanisms of amyloid formation revealed by solution NMRAssessing the causes and consequences of co-polymerization in amyloid formationTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseAldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's diseaseExploring the accessible conformations of N-terminal acetylated α-synucleinPathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseBreaking the Code of Amyloid-β OligomersA flash in the pan: dissecting dynamic amyloid intermediates using fluorescenceThe relationship between amyloid structure and cytotoxicityPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Out-of-register -sheets suggest a pathway to toxic amyloid aggregatesA Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril FormationA Fibril-Like Assembly of Oligomers of a Peptide Derived from β-AmyloidSeeking a mechanism for the toxicity of oligomeric α-synucleinSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsInter-species cross-seeding: stability and assembly of rat-human amylin aggregatesβ2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pHAmyloid-β oligomers are sequestered by both intracellular and extracellular chaperonesTwo-Step Amyloid Aggregation: Sequential Lag Phase IntermediatesEarly amyloidogenic oligomerization studied through fluorescence lifetime correlation spectroscopy.Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synucleinα-Synuclein mutations cluster around a putative protein loop.Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulationThe Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicityStructural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core.Structural characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase protofibrils preventing α-synuclein oligomeric species toxicitySolution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregationSoluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.
P2860
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P2860
Direct observation of the interconversion of normal and toxic forms of α-synuclein
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@ast
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@en
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@nl
type
label
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@ast
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@en
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@nl
prefLabel
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@ast
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@en
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@nl
P2093
P2860
P50
P1433
P1476
Direct observation of the interconversion of normal and toxic forms of α-synuclein
@en
P2093
Christopher M Dobson
Paul Dunne
Samuel I A Cohen
P2860
P304
P356
10.1016/J.CELL.2012.03.037
P407
P50
P577
2012-05-01T00:00:00Z