Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
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The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisCa2+ binding to alpha-synuclein regulates ligand binding and oligomerizationAlpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicityParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelProteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactionsUpregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophagesLRRK2 phosphorylates novel tau epitopes and promotes tauopathyMisfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathiesDorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosisSystematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activitiesThe benefits of humanized yeast models to study Parkinson's diseaseAlpha-synuclein biology in Lewy body diseasesImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseCasein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formationThe casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expressionDegradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neuronsPhosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiaePhosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsAssessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.alpha-Synuclein affects the MAPK pathway and accelerates cell death.Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomersSelf-oligomerization and protein aggregation of alpha-synuclein in the presence of Coomassie Brilliant Blue.Phosphorylation of synucleins by members of the Polo-like kinase family.Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent mannerParkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Dynamic changes of the phosphoproteome in postmortem mouse brains.Resolving acetylated and phosphorylated proteins by neutral urea Triton-polyacrylamide gel electrophoresis: NUT-PAGESpecificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Direct observation of the interconversion of normal and toxic forms of α-synucleinLewy bodies.Glial cell inclusions and the pathogenesis of neurodegenerative diseasesEvaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease.
P2860
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P2860
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
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2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@ast
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@en
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@nl
type
label
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@ast
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@en
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@nl
altLabel
Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein
@en
prefLabel
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@ast
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@en
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@nl
P2093
P921
P3181
P356
P1476
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
@en
P2093
T Iwatsubo
P304
P3181
P356
10.1074/JBC.275.1.390
P407
P577
2000-01-01T00:00:00Z