The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. - Wikidata - wikimedia - TriplyDB

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.

http://www.wikidata.org/entity/Q34281428

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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance Recent advances in understanding hepatitis C Interferon-λ: Immune Functions at Barrier Surfaces and Beyond Immune responses to HCV and other hepatitis viruses Post-transcriptional regulation of interferons and their signaling pathways Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions Influence of host resistance on viral adaptation: hepatitis C virus as a case study Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C.Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome.Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4)Interferon lambda: opportunities, risks, and uncertainties in the fight against HCV.IFN-λ4: the paradoxical new member of the interferon lambda family.Host Genetic Factors and Dendritic Cell Responses Associated with the Outcome of Interferon/Ribavirin Treatment in HIV-1/HCV Co-Infected Individuals.Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.Detection of allele specific differences in IFNL3 (IL28B) mRNA expression Hepatitis C Virus. Strategies to Evade Antiviral Responses MicroRNAs: Role in Hepatitis C Virus pathogenesis Landscape of post-transcriptional gene regulation during hepatitis C virus infection Hepatic Interferon-λ3 (IFNL3) Gene Expression Reveals Not to Be Attenuated in Non-Favorable IFNL3 rs4803217 or IFNL4 rs368234815 Minor Allele Carriers in Chronic Hepatitis C.Is the use of IL28B genotype justified in the era of interferon-free treatments for hepatitis C?Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection.Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis.Interferon lambda 4 expression is suppressed by the host during viral infection.Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth.MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection?Innate and adaptive genetic pathways in HCV infection.Insights into antiviral innate immunity revealed by studying hepatitis C virus.The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.Translating the Untranslated Region.Human Genetic Determinants of Viral Diseases.Host-virus interactions in hepatitis B and hepatitis C infection.Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.Targeting IFN-λ: therapeutic implications.Organ system view of the hepatic innate immunity in HCV infection.Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections.Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians.

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The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.

http://www.wikidata.org/entity/Q34281428

description

2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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name

The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.

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The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.

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The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.

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The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.

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Nature Immunology

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Abigail Jarret

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Bruce A Shapiro

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Curt H Hagedorn

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Don A Delker

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Eckart Bindewald

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Ram Savan

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Rochelle C Joslyn

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Stacy M Horner

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P2860

ViennaRNA Package 2.0

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

IL-28, IL-29 and their class II cytokine receptor IL-28R

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

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72-79

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10.1038/NI.2758

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1

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15

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Mary Carrington

Adelle P McFarland

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2013-11-17T00:00:00Z

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258637335

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