The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.
about
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesIFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearanceRecent advances in understanding hepatitis CInterferon-λ: Immune Functions at Barrier Surfaces and BeyondImmune responses to HCV and other hepatitis virusesPost-transcriptional regulation of interferons and their signaling pathwaysGenetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactionsInfluence of host resistance on viral adaptation: hepatitis C virus as a case studyInterferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burdenPrevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C.Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome.Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4)Interferon lambda: opportunities, risks, and uncertainties in the fight against HCV.IFN-λ4: the paradoxical new member of the interferon lambda family.Host Genetic Factors and Dendritic Cell Responses Associated with the Outcome of Interferon/Ribavirin Treatment in HIV-1/HCV Co-Infected Individuals.Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.Detection of allele specific differences in IFNL3 (IL28B) mRNA expressionHepatitis C Virus. Strategies to Evade Antiviral ResponsesMicroRNAs: Role in Hepatitis C Virus pathogenesisLandscape of post-transcriptional gene regulation during hepatitis C virus infectionHepatic Interferon-λ3 (IFNL3) Gene Expression Reveals Not to Be Attenuated in Non-Favorable IFNL3 rs4803217 or IFNL4 rs368234815 Minor Allele Carriers in Chronic Hepatitis C.Is the use of IL28B genotype justified in the era of interferon-free treatments for hepatitis C?Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma RiskViral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection.Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis.Interferon lambda 4 expression is suppressed by the host during viral infection.Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth.MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection?Innate and adaptive genetic pathways in HCV infection.Insights into antiviral innate immunity revealed by studying hepatitis C virus.The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.Translating the Untranslated Region.Human Genetic Determinants of Viral Diseases.Host-virus interactions in hepatitis B and hepatitis C infection.Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.Targeting IFN-λ: therapeutic implications.Organ system view of the hepatic innate immunity in HCV infection.Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections.Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians.
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P2860
The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@ast
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@en
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@nl
type
label
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@ast
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@en
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@nl
prefLabel
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@ast
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@en
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@nl
P2093
P2860
P50
P356
P1433
P1476
The favorable IFNL3 genotype e ...... tis C virus-induced microRNAs.
@en
P2093
Abigail Jarret
Bruce A Shapiro
Curt H Hagedorn
Don A Delker
Eckart Bindewald
Rochelle C Joslyn
Stacy M Horner
P2860
P2888
P356
10.1038/NI.2758
P407
P577
2013-11-17T00:00:00Z
P5875
P6179
1050809541