A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity
about
Alternatively spliced isoforms of the human constitutive androstane receptorComplex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CARAlternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorThe evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsActivation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateStructural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationMolecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Helix 11 dynamics is critical for constitutive androstane receptor activity.Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.Drug-activated nuclear receptors CAR and PXR.Multi-species analyses of direct activators of the constitutive androstane receptor.CAR and PXR: the xenobiotic-sensing receptors.Deciphering the roles of the constitutive androstane receptor in energy metabolism.CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetryXenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveStructure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.Negative regulation by nuclear receptors: a plethora of mechanisms.Regulation of gene expression by CAR: an update.Modelling approaches for evaluating multiscale tendon mechanics.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.Amino acids important for ligand specificity of the human constitutive androstane receptor.Dual action of oestrogens on the mouse constitutive androstane receptor.DNA-induced unfolding of the thyroid hormone receptor α A/B domain through allostery.Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants.Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs.Allosteric pathways in nuclear receptors - Potential targets for drug design.Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction.Constitutive activity and ligand-dependent activation of the nuclear receptor CAR-insights from molecular dynamics simulations.In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets
P2860
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P2860
A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A structural model of the cons ...... te ligand-independent activity
@ast
A structural model of the cons ...... te ligand-independent activity
@en
A structural model of the cons ...... te ligand-independent activity
@nl
type
label
A structural model of the cons ...... te ligand-independent activity
@ast
A structural model of the cons ...... te ligand-independent activity
@en
A structural model of the cons ...... te ligand-independent activity
@nl
prefLabel
A structural model of the cons ...... te ligand-independent activity
@ast
A structural model of the cons ...... te ligand-independent activity
@en
A structural model of the cons ...... te ligand-independent activity
@nl
P2093
P2860
P1476
A structural model of the cons ...... te ligand-independent activity
@en
P2093
Barry M Forman
Isabelle Dussault
John Termini
Kevin Hollister
Mark A Sherman
P2860
P304
P356
10.1128/MCB.22.15.5270-5280.2002
P407
P577
2002-08-01T00:00:00Z