Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.
about
Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestorIdentification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptorEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Modulation of xenobiotic receptors by steroidsCoupling of receptor conformation and ligand orientation determine graded activityStructural basis for negative cooperativity within agonist-bound TR:RXR heterodimersA brief history of the discovery of PXR and CAR as xenobiotic receptorsTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationRetinoic acid actions through mammalian nuclear receptors.Evolution of pharmacologic specificity in the pregnane X receptor.The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorConstitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.Structural and functional insights into nuclear receptor signaling.Helix 11 dynamics is critical for constitutive androstane receptor activity.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARCYP2B6: new insights into a historically overlooked cytochrome P450 isozymeMulti-species analyses of direct activators of the constitutive androstane receptor.Small-molecule modulators of the constitutive androstane receptor.Nuclear receptors CAR and PXR in the regulation of hepatic metabolism.Small-molecule modulators of PXR and CAR.CAR and PXR: the xenobiotic-sensing receptors.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Role of CAR and PXR in xenobiotic sensing and metabolism.Human PXR forms a tryptophan zipper-mediated homodimerThermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetryXenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveSignaling control of the constitutive androstane receptor (CAR)Orphan nuclear receptors as targets for drug development.Negative regulation by nuclear receptors: a plethora of mechanisms.Nuclear receptors and nonalcoholic fatty liver disease.DNA-induced unfolding of the thyroid hormone receptor α A/B domain through allostery.Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation.Allosteric pathways in nuclear receptors - Potential targets for drug design.Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets
P2860
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P2860
Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structure of the murine consti ...... lar basis for inverse agonism.
@en
Structure of the murine consti ...... lar basis for inverse agonism.
@nl
type
label
Structure of the murine consti ...... lar basis for inverse agonism.
@en
Structure of the murine consti ...... lar basis for inverse agonism.
@nl
prefLabel
Structure of the murine consti ...... lar basis for inverse agonism.
@en
Structure of the murine consti ...... lar basis for inverse agonism.
@nl
P2093
P2860
P1433
P1476
Structure of the murine consti ...... lar basis for inverse agonism.
@en
P2093
Barry M Forman
Elias J Fernandez
Irina Ianculescu
Isabelle Dussault
Jeremy Vincent
Joseph S Brunzelle
Mark A Sherman
P2860
P304
P356
10.1016/S1097-2765(04)00728-2
P577
2004-12-01T00:00:00Z