ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation. - Wikidata - wikimedia - TriplyDB

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

http://www.wikidata.org/entity/Q34290357

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Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism To pull or be pulled: parsing the multiple modes of mechanotransduction.Fibronectin matrix assembly is essential for cell condensation during chondrogenesis.Influence of the microenvironment on cell fate determination and migration The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds A developmentally inspired combined mechanical and biochemical signaling approach on zonal lineage commitment of mesenchymal stem cells in articular cartilage regeneration The combined effects of matrix stiffness and growth factor immobilization on the bioactivity and differentiation capabilities of adipose-derived stem cells Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage.The effect of matrix stiffness on biomechanical properties of chondrocytes.Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension Extracellular matrix stiffness dictates Wnt expression through integrin pathway Comparative effect of physicomechanical and biomolecular cues on zone-specific chondrogenic differentiation of mesenchymal stem cells.Matrix stiffness promotes cartilage endplate chondrocyte calcification in disc degeneration via miR-20a targeting ANKH expression.Mechanobiology of TGFβ signaling in the skeleton.Ageing and the pathogenesis of osteoarthritis.Mechanical loading inhibits hypertrophy in chondrogenically differentiating hMSCs within a biomimetic hydrogel.The Effect of Gradations in Mineral Content, Matrix Alignment, and Applied Strain on Human Mesenchymal Stem Cell Morphology within Collagen Biomaterials.Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway Fibronectin at select sites binds multiple growth factors and enhances their activity: expansion of the collaborative ECM-GF paradigm.Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis.Cyclic tensile strain enhances human mesenchymal stem cell Smad 2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds.Clinical use of stem cells in orthopaedics Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling.Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.Prenatal exposure to environmental factors and congenital limb defects.Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.Improving cartilage phenotype from differentiated pericytes in tunable peptide hydrogels.Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves Multi-lineage differentiation of human mesenchymal stromal cells on the biophysical microenvironment of cell-derived matrix.Tunable Microfibers Suppress Fibrotic Encapsulation via Inhibition of TGFβ Signaling.YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity.Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.

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P2860

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

http://www.wikidata.org/entity/Q34290357

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

@ast

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

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ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

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type

label

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

@ast

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

@en

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

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prefLabel

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

@ast

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

@en

ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

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MBC.E12-03-0172

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Molecular Biology of the Cell

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ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

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P2093

Jessica L Allen

http://www.w3.org/2001/XMLSchema#string

Margaret E Cooke

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Tamara Alliston

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P2860

TGF-beta signal transduction

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Growth control by intracellular tension and extracellular stiffness

The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

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3731-3742

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10.1091/MBC.E12-03-0172

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18

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