Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes. - Wikidata - wikimedia - TriplyDB

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.

http://www.wikidata.org/entity/Q34292432

about

Li-fraumeni syndrome Myosin VI is a mediator of the p53-dependent cell survival pathway.Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53 p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA Differential correlation for sequencing data.In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs.Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53, CDKN2A and N-Ras genes.Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers Degradation of mutant p53H175 protein by Zn(II) through autophagy.Characterization of functional domains necessary for mutant p53 gain of function.p53-mediated hematopoietic stem and progenitor cell competition.Limited importance of the dominant-negative effect of TP53 missense mutations Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53 Re-engineered p53 chimera with enhanced homo-oligomerization that maintains tumor suppressor activity.Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions.Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model.Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells.A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect.Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis Post-translational modification of p53 in tumorigenesis.CCN5/WISP-2: A micromanager of breast cancer progression Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).

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P2860

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.

http://www.wikidata.org/entity/Q34292432

description

2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Mutant p53 exerts a dominant n ...... promoter of its target genes.

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Mutant p53 exerts a dominant n ...... promoter of its target genes.

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Mutant p53 exerts a dominant n ...... promoter of its target genes.

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Mutant p53 exerts a dominant n ...... promoter of its target genes.

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P2093

Amy Willis

http://www.w3.org/2001/XMLSchema#string

Eun Joo Jung

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Therese Wakefield

http://www.w3.org/2001/XMLSchema#string

Xinbin Chen

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P2860

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

p53 modulation of TFIIH-associated nucleotide excision repair activity

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

WAF1, a potential mediator of p53 tumor suppression

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

Oncogenic forms of p53 inhibit p53-regulated gene expression

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

P2888

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2330-2338

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scholarly article

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10.1038/SJ.ONC.1207396

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13

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23

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2004-03-01T00:00:00Z

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8903606

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1023930052

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14743206

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