Telomere maintenance mechanisms as a target for drug development.
about
Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells.Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors.Cation involvement in telomestatin binding to g-quadruplex DNA.Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates.Telomerase inhibition, oligonucleotides, and clinical trials.Telomere maintenance as a target for anticancer drug discovery.Biophysical and biological properties of quadruplex oligodeoxyribonucleotidesTelomere biology of human hematopoietic stem cells.Gas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations.Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cellsEvaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.Baculoviral expression of telomerase in primary human fibroblasts to rejuvenate cells for tissue engineering.Specific interactions of distamycin with G-quadruplex DNA.Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells.Antitumour polycyclic acridines. Palladium(0) mediated syntheses of quino[4,3,2-kl]acridines bearing peripheral substituents as potential telomere maintenance inhibitors.Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways.On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids.Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.
P2860
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P2860
Telomere maintenance mechanisms as a target for drug development.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Telomere maintenance mechanisms as a target for drug development.
@ast
Telomere maintenance mechanisms as a target for drug development.
@en
Telomere maintenance mechanisms as a target for drug development.
@nl
type
label
Telomere maintenance mechanisms as a target for drug development.
@ast
Telomere maintenance mechanisms as a target for drug development.
@en
Telomere maintenance mechanisms as a target for drug development.
@nl
prefLabel
Telomere maintenance mechanisms as a target for drug development.
@ast
Telomere maintenance mechanisms as a target for drug development.
@en
Telomere maintenance mechanisms as a target for drug development.
@nl
P2860
P356
P1433
P1476
Telomere maintenance mechanisms as a target for drug development.
@en
P2093
Von Hoff DD
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204092
P407
P577
2000-12-01T00:00:00Z
P5875
P6179
1027816768