The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. - Wikidata - wikimedia - TriplyDB

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

http://www.wikidata.org/entity/Q34296908

about

The role of HDAC6 in cancer A novel GRK2/HDAC6 interaction modulates cell spreading and motility A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation.Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6.The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.HDAC6 inhibition restores ciliary expression and decreases tumor growth Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.Regulation of ku70-bax complex in cells.Histone deacetylases and cancer.Increasing CD44+/CD24(-) tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.Differences in microRNA expression during tumor development in the transition and peripheral zones of the prostate.HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma.Expression of histone deacetylases in lymphoma: implication for the development of selective inhibitors.Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study.Nonhistone protein acetylation as cancer therapy targets.HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma.Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression.Overexpression of Histone Deacetylase 6 Enhances Resistance to Porcine Reproductive and Respiratory Syndrome Virus in Pigs.Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori.Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer.Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation

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The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

http://www.wikidata.org/entity/Q34296908

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@ast

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@en

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@nl

type

label

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@ast

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@en

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@nl

prefLabel

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@ast

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@en

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.

@nl

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0008-5472.CAN-08-0188

P1433

Cancer Research

P1476

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis

@en

P2093

Christopher M Counter

http://www.w3.org/2001/XMLSchema#string

Peter Ordentlich

http://www.w3.org/2001/XMLSchema#string

Tomasa Barrientos

http://www.w3.org/2001/XMLSchema#string

Tso-Pang Yao

http://www.w3.org/2001/XMLSchema#string

Xiao-Fan Wang

http://www.w3.org/2001/XMLSchema#string

Xing Guo

http://www.w3.org/2001/XMLSchema#string

Yasheng Gao

http://www.w3.org/2001/XMLSchema#string

Yi-Shan Lee

http://www.w3.org/2001/XMLSchema#string

Yoshiharu Kawaguchi

http://www.w3.org/2001/XMLSchema#string

P2860

HDAC6 is a microtubule-associated deacetylase

Class II histone deacetylases: versatile regulators

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Disruption of epithelial cell-matrix interactions induces apoptosis

Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis

The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

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7561-7569

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10.1158/0008-5472.CAN-08-0188

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18

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68

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2978070

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