The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
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The role of HDAC6 in cancerA novel GRK2/HDAC6 interaction modulates cell spreading and motilityA novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growthThe protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent mannerHDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signalingClass IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactinHistone deacetylase 6 plays a role as a distinct regulator of diverse cellular processesΑ-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesionThe cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation.Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6.The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.Effect of EGF-induced HDAC6 activation on corneal epithelial wound healingPaxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.HDAC6 inhibition restores ciliary expression and decreases tumor growthKnock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.Regulation of ku70-bax complex in cells.Histone deacetylases and cancer.Increasing CD44+/CD24(-) tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesisDepletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cellsManipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humansHDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.Differences in microRNA expression during tumor development in the transition and peripheral zones of the prostate.HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma.Expression of histone deacetylases in lymphoma: implication for the development of selective inhibitors.Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study.Nonhistone protein acetylation as cancer therapy targets.HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma.Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast CancerUpregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression.Overexpression of Histone Deacetylase 6 Enhances Resistance to Porcine Reproductive and Respiratory Syndrome Virus in Pigs.Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori.Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer.Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiationTubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation
P2860
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P2860
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@ast
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@en
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@nl
type
label
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@ast
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@en
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@nl
prefLabel
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@ast
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@en
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
@nl
P2093
P2860
P1433
P1476
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis
@en
P2093
Christopher M Counter
Peter Ordentlich
Tomasa Barrientos
Tso-Pang Yao
Xiao-Fan Wang
Yasheng Gao
Yi-Shan Lee
Yoshiharu Kawaguchi
P2860
P304
P356
10.1158/0008-5472.CAN-08-0188
P407
P577
2008-09-01T00:00:00Z