ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. - Wikidata - wikimedia - TriplyDB

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

http://www.wikidata.org/entity/Q34298505

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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy DNA damage response and prostate cancer: defects, regulation and therapeutic implications Divorcing ARF and p53: an unsettled case The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage Inferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis Deciphering c-MYC-regulated genes in two distinct tissues.Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis MYC and the control of DNA replication.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation Oncogenic stress sensed by the immune system: role of natural killer cell receptors Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells Antisense oligodeoxynucleotides targeting ATM strengthen apoptosis of laryngeal squamous cell carcinoma grown in nude mice Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.Tug of war between survival and death: exploring ATM function in cancer.Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases.A mouse model for the molecular characterization of brca1-associated ovarian carcinoma Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.c-Myc suppression of DNA double-strand break repair.The ATR barrier to replication-born DNA damage.The ATM signaling network in development and disease.c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis Apoptotic signaling by c-MYC.Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.Histone H2AX suppresses translocations in lymphomas of Eμ-c-Myc transgenic mice that contain a germline amplicon of tumor-promoting genes Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance.Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.Genetic analysis of oral squamous cell carcinoma by cDNA microarrays focused apoptotic pathway.Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.The Evaluation and Comparison of Transcriptionally Targeted Noxa and Puma Killer Genes to Initiate Apoptosis Under Cancer-Specific Promoter CXCR1 in Hepatocarcinoma Gene Therapy

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ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

http://www.wikidata.org/entity/Q34298505

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@ast

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@en

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

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type

label

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@ast

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@en

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@nl

prefLabel

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@ast

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@en

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

@en

P2093

David G Johnson

http://www.w3.org/2001/XMLSchema#string

John T Powers

http://www.w3.org/2001/XMLSchema#string

Kaoru Kiguchi

http://www.w3.org/2001/XMLSchema#string

Mark J McArthur

http://www.w3.org/2001/XMLSchema#string

Mingshan Yan

http://www.w3.org/2001/XMLSchema#string

Paul K Wong

http://www.w3.org/2001/XMLSchema#string

Raju V Pusapati

http://www.w3.org/2001/XMLSchema#string

Robert J Rounbehler

http://www.w3.org/2001/XMLSchema#string

SungKi Hong

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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1446-1451

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10.1073/PNAS.0507367103

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5

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103

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16432227

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