Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases.
about
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersCyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancersEndoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaHzf Determines cell survival upon genotoxic stress by modulating p53 transactivationp53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageThe requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.ZBP-89 promotes growth arrest through stabilization of p53The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sitesp53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent mannerThe interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigenik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cellsModification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoproteinCdk5 phosphorylates p53 and regulates its activityDNA damage activates p53 through a phosphorylation-acetylation cascadeFactors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain.Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.Kinetics of p53 binding to promoter sites in vivo.Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localizationCyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic responseA novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.Molecular interaction map of the mammalian cell cycle control and DNA repair systems.USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.Mechanisms of switching on p53: a role for covalent modification?The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.Cell-cycle regulation of the p53-inducible gene B99.Tumor suppressor p53 is required to modulate BRCA1 expression.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressStrategies for manipulating the p53 pathway in the treatment of human cancer.Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivoA decade of site- and phosphorylation state-specific antibodies: recent advances in studies of spatiotemporal protein phosphorylation.Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.Protein kinase C inhibitors as novel anticancer drugs.The evolution of diverse biological responses to DNA damage: insights from yeast and p53.Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).
P2860
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P2860
Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@ast
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@en
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@nl
type
label
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@ast
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@en
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@nl
prefLabel
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@ast
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@en
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@nl
P356
P1433
P1476
Increased and altered DNA bind ...... t G1 cyclin-dependent kinases.
@en
P2888
P356
10.1038/376088A0
P407
P577
1995-07-01T00:00:00Z
P6179
1049499733