Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons.
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No evidence of locus heterogeneity in familial microcephaly with or without chorioretinopathy, lymphedema, or mental retardation syndromeKinesin-5: cross-bridging mechanism to targeted clinical therapyKinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migrationKinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.Kinesin-5 is essential for growth-cone turningKinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell lineMicrotubule plus-end tracking proteins in neuronal developmentPavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons.The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrolIncreased spinal cord Na⁺-K⁺-2Cl⁻ cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic painEffects of kinesin-5 inhibition on dendritic architecture and microtubule organization.Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.Kinesin molecular motor Eg5 functions during polypeptide synthesis.Measurement of subcellular force generation in neurons.Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrolSynthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line.Transport and diffusion of Tau protein in neurons.Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth.Modulating motility of intracellular vesicles in cortical neurons with nanomagnetic forces on-chip.Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.Developmental expression and role of Kinesin Eg5 during Xenopus laevis embryogenesis.Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells.Synthesis and biological evaluation of novel EG5 inhibitors.Interference with kinesin-based anterograde neurofilament axonal transport increases neurofilament-neurofilament bundling.Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs
P2860
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P2860
Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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name
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@ast
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@en
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@nl
type
label
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@ast
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@en
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@nl
prefLabel
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@ast
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@en
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@nl
P2093
P356
P1433
P1476
Monastrol, a prototype anti-ca ...... cultured postmitotic neurons.
@en
P2093
Ari D Brooks
Pavel V Lobanov
Peter W Baas
Saad A Haque
Thomas P Hasaka
P356
10.1002/CM.10176
P577
2004-05-01T00:00:00Z