Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.
about
Molecular defects associated with the acute phase CML.p53 mutations in colorectal cancerP53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.p53 functions as a cell cycle control protein in osteosarcomasIdentification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.Malignancy: Tumor Suppressor Gene Aberrations in Acute Myelogenous Leukemia.Loss of p53 impedes the antileukemic response to BCR-ABL inhibitionCBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemiaMolecular mechanisms in the evolution of chronic myelocytic leukemia.A DNA binding domain is contained in the C-terminus of wild type p53 proteinProgressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia.Dasatinib: the emerging evidence of its potential in the treatment of chronic myeloid leukemia.Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA techniqueA novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.p53 mutation and expression in lymphomaCentrosome aberrations--hen or egg in cancer initiation and progression?Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemiaExpression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell linesAnalysis of p53 mutants for transcriptional activity.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaTargeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.Individual telomere lengths in chronic myeloid leukemia.p53 in chronic myelogenous leukemia in acute phase.Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.Involvement of wild-type p53 in pre-B-cell differentiation in vitro.Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism.Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.The p53 tumor suppressor protein regulates hematopoietic stem cell fate.TP53 mutation analysis in clinical practice: lessons from chronic lymphocytic leukemia.A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells.Wild-type p53 induces diverse effects in 32D cells expressing different oncogenes.Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.Expression of wild-type and mutant p53 proteins by recombinant vaccinia viruses.
P2860
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P2860
Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.
description
1989 nî lūn-bûn
@nan
1989 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@ast
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@en
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@nl
type
label
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@ast
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@en
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@nl
prefLabel
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@ast
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@en
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@nl
P2093
P2860
P356
P1476
Alterations in the p53 gene an ...... f chronic myelocytic leukemia.
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.17.6783
P407
P577
1989-09-01T00:00:00Z