A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion - Wikidata - wikimedia - TriplyDB

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

http://www.wikidata.org/entity/Q34306163

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Cardiac cAMP: production, hydrolysis, modulation and detection Mechanical allodynia Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1 Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses Cyclic AMP sensor EPAC proteins and energy homeostasis.Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.The future of EPAC-targeted therapies: agonism versus antagonism Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation [corrected]Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1 Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.EP2 receptor signaling pathways regulate classical activation of microglia.Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.The Steroid Hormone 20-Hydroxyecdysone Enhances Gene Transcription through the cAMP Response Element-binding Protein (CREB) Signaling Pathway.Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1.Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac.Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

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A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

http://www.wikidata.org/entity/Q34306163

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@ast

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@en

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@nl

type

label

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@ast

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@en

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@nl

prefLabel

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@ast

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@en

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@nl

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Molecular Pharmacology

P1476

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

@en

P2093

Fang C Mei

http://www.w3.org/2001/XMLSchema#string

Frank Schwede

http://www.w3.org/2001/XMLSchema#string

Haijun Chen

http://www.w3.org/2001/XMLSchema#string

Jia Zhou

http://www.w3.org/2001/XMLSchema#string

Muayad Almahariq

http://www.w3.org/2001/XMLSchema#string

Sarita K Sastry

http://www.w3.org/2001/XMLSchema#string

Tamara Tsalkova

http://www.w3.org/2001/XMLSchema#string

Xiaodong Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

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122-128

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scholarly article

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10.1124/MOL.112.080689

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1

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83

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2012-10-11T00:00:00Z

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232248280

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23066090

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3533471

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