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Isoform-specific antagonists of exchange proteins directly activated by cAMP

Isoform-specific antagonists of exchange proteins directly activated by cAMP

http://www.wikidata.org/entity/Q34307662

about

Structure-guided design of selective Epac1 and Epac2 agonists Cardiac cAMP: production, hydrolysis, modulation and detection Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1 Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses Cyclic AMP sensor EPAC proteins and energy homeostasis.Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.The future of EPAC-targeted therapies: agonism versus antagonism Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Circadian rhythms. A protein fold switch joins the circadian oscillator to clock output in cyanobacteria.Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling.Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Increased microvascular permeability in mice lacking Epac1 (Rapgef3).Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation.Epac proteins: specific ligands and role in cardiac remodelling.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.The role of Epac in the heart.Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition.Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue.Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.

P2860

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P2860

Isoform-specific antagonists of exchange proteins directly activated by cAMP

http://www.wikidata.org/entity/Q34307662

description

2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@ast

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@en

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@nl

type

label

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@ast

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@en

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@nl

prefLabel

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@ast

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@en

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@nl

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PNAS.1210209109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Isoform-specific antagonists of exchange proteins directly activated by cAMP

@en

P2093

Colin A Leech

http://www.w3.org/2001/XMLSchema#string

Fang C Mei

http://www.w3.org/2001/XMLSchema#string

George G Holz

http://www.w3.org/2001/XMLSchema#string

Oleg G Chepurny

http://www.w3.org/2001/XMLSchema#string

Sheng Li

http://www.w3.org/2001/XMLSchema#string

Tamara Tsalkova

http://www.w3.org/2001/XMLSchema#string

Tong Liu

http://www.w3.org/2001/XMLSchema#string

Virgil L Woods

http://www.w3.org/2001/XMLSchema#string

Xiaodong Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

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18613-18618

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scholarly article

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10.1073/PNAS.1210209109

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45

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109

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2012-10-22T00:00:00Z

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232611466

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23091014

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3494926

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