Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
about
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designChemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasisMini review on tricyclic compounds as an inhibitor of trypanothione reductaseComparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruziDihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyA critical review on Chagas disease chemotherapyInvestigation of trypanothione reductase as a drug target in Trypanosoma brucei.Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.Moving from unsequenced to sequenced genome: reanalysis of the proteome of Leishmania donovani.Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes.Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculataA second class of peroxidases linked to the trypanothione metabolism.8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase
P2860
Q24616801-1486BF70-DC41-4DFB-BDE8-FEC92506FA75Q24657204-027B64AF-7114-4877-ACD7-238FBCE95B7DQ26852541-C60E236D-CDA3-44DF-9035-0F2D6AFEE398Q27657406-F71C9444-AE57-49F9-AF27-155D4A8588ECQ27671819-EE38F0C1-3C62-4DFD-B28E-4AE1C44F4902Q28216601-46E643C9-2947-47D7-A20D-1AD397605F39Q30897674-704324F2-19D5-47D9-BAB9-07C26CBB4BC0Q31142265-FD95DB18-D873-4C4E-BD56-7CEFEF95C188Q33966094-8DA8B111-91FF-4FE7-9408-A8BA9E1AC088Q34088830-9A1355AC-F555-4D7A-80A0-E0589111AE90Q34097455-98FE0EC5-DFB6-4E2E-8598-41417D121F25Q34139347-67A5EA67-4708-444B-94EE-E2A1F192F012Q36454920-1EE6A4F9-3CAA-480A-86FD-3D66CB18C7F3Q37254812-F061DAC5-6088-4E49-AFEF-A590385A0B72Q37333136-89DB0BA5-C5FB-4BA6-BAEE-C17E5B9729E4Q39814149-4FF8F02A-7ED5-499A-B72B-6AB41BF4A3C1Q40544348-9017797C-7CEF-4EC4-A6A6-3BFBFCEF42AEQ41781992-2C00848B-D67F-4A80-8680-420E1970EE65Q41824183-F943AECB-2155-4A5F-9F40-E7476E01FDA8Q42094447-184581B0-AD4F-4C2C-AF56-EFD097A5B0C0Q44238562-1119E547-99D9-43CA-B346-6371B51E8EA3Q58850134-1F9095FD-CBEB-4E63-82A7-C75998422AF9
P2860
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@ast
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@en
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@nl
type
label
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@ast
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@en
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@nl
prefLabel
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@ast
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@en
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@nl
P2093
P356
P1476
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
@en
P2093
P304
P356
10.2174/1381612013397564
P577
2001-08-01T00:00:00Z