The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition. - Wikidata - wikimedia - TriplyDB

The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.

The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.

http://www.wikidata.org/entity/Q34330487

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Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase X-ray Crystal Structure of Arsenite-Inhibited Xanthine Oxidase: μ-Sulfido,μ-Oxo Double Bridge between Molybdenum and Arsenic in the Active Site The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes.Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol The mononuclear molybdenum enzymes.Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710 Molybdenum enzymes in higher organisms.Xanthine oxidoreductase reference values in platelet-poor plasma and platelets in healthy volunteers Chalcogenidobis(ene-1,2-dithiolate)molybdenum(IV) complexes (chalcogenide E = O, S, Se): probing Mo≡E and ene-1,2-dithiolate substituent effects on geometric and electronic structure.Archaeal Mo-Containing Glyceraldehyde Oxidoreductase Isozymes Exhibit Diverse Substrate Specificities through Unique Subunit Assemblies.Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment.Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans.Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase.Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study.Increasing recognition of the importance of aldehyde oxidase in drug development and discovery.Xanthine oxidase inhibitors: a patent survey.Chemical nature and reaction mechanisms of the molybdenum cofactor of xanthine oxidoreductase Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans.Electronic structure contributions to reactivity in xanthine oxidase family enzymes.Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases.Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice.Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases.Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?On the purification and preliminary crystallographic analysis of isoquinoline 1-oxidoreductase from Brevundimonas diminuta 7 Studies on the mechanism of aldehyde oxidase and xanthine oxidase.Purification, characterization, and cloning of a bifunctional molybdoenzyme with hydratase and alcohol dehydrogenase activity.Modeling the transition state structure to probe a reaction mechanism on the oxidation of quinoline by quinoline 2-oxidoreductase.The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus: the role of Glu232 in catalysis.Study on species differences in nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor.Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids.Oxo-sulfido- and oxo-selenido-molybdenum(VI) complexes possessing a dithiolene ligand related to the active sites of hydroxylases of molybdoenzymes: low temperature preparation and characterisation.

P2860

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P2860

The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.

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The crystal structure of xanth ...... chanism and enzyme inhibition.

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Bryan T Eger

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Ken Okamoto

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Koji Matsumoto

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P2860

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution.

Raster3D: photorealistic molecular graphics

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

Rapid automated molecular replacement by evolutionary search

Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas

Efficient rebuilding of protein structures.

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crystal structure

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