G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. - Wikidata - wikimedia - TriplyDB

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

http://www.wikidata.org/entity/Q34335126

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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease Propagation of prions causing synucleinopathies in cultured cells Untangling the Manganese-α-Synuclein Web Versatile Structures of α-Synuclein Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson's Disease Dynamic structural flexibility of α-synuclein Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation Mechanism of Anti-α-Synuclein Immunotherapy Fish Synucleins: An Update Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism Relevance of chronic stress and the two faces of microglia in Parkinson's disease Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease Biophysical characterization of α-synuclein and its controversial structure Alpha-synuclein biology in Lewy body diseases Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The Synaptic Function of α-Synuclein C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application Seeking a mechanism for the toxicity of oligomeric α-synuclein Alpha-synuclein spreading in Parkinson's disease Drosophila as an In Vivo Model for Human Neurodegenerative Disease ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication The Monoamine Brainstem Reticular Formation as a Paradigm for Re-Defining Various Phenotypes of Parkinson's Disease Owing Genetic and Anatomical Specificity.α-Synuclein mutations cluster around a putative protein loop.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Pathological alpha-synuclein propagates through neural networks Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.The genetic background of Parkinson's disease: current progress and future prospects.Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation Exploring Braak's Hypothesis of Parkinson's Disease.Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

http://www.wikidata.org/entity/Q34335126

description

2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@ast

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@en

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@nl

type

label

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@en

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@nl

prefLabel

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@ast

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

@en

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

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Annals of Neurology

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

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Aurélie Honoré

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Christophe Verny

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Franck Letournel

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Karine Madiona

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Laura Pieri

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Luc Bousset

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Nelly Rozas

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Ronald Melki

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P2860

Fast and accurate short read alignment with Burrows-Wheeler transform

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

The Sequence Alignment/Map format and SAMtools

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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459-471

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10.1002/ANA.23894

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4

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73

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French Parkinson's Disease Genetics Study Group

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2013-04-01T00:00:00Z

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23526723

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P921

Parkinson's disease