Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
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Ubc13: the Lys63 ubiquitin chain building machineDrugging the undruggables: exploring the ubiquitin system for drug developmentWhen ubiquitin meets NF-κB: a trove for anti-cancer drug developmentDeconstructing innate immune signaling in myelodysplastic syndromesMLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation.Protein ubiquitination in lymphoid malignancies.Screening of DUB activity and specificity by MALDI-TOF mass spectrometryCovalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signalingThe anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Emerging roles of Lys63-linked polyubiquitylation in immune responses.XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys63-linked polyubiquitination.A Generic Platform for Cellular Screening Against Ubiquitin Ligases.Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.MicroRNAs as predictors for CNS relapse of systemic diffuse large B-cell lymphoma.MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling.Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.PKK deficiency in B cells prevents lupus development in Sle lupus mice.Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus TranslocationNew Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer.Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation.Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulationDynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes
P2860
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P2860
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@ast
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@en
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@nl
type
label
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@ast
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@en
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@nl
prefLabel
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@ast
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@en
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@nl
P2093
P2860
P1433
P1476
Inhibition of proliferation an ...... onjugating enzyme Ubc13-Uev1A.
@en
P2093
David Oleksyn
Elise Van Pelt
Ignacio Sanz
Jiyong Zhao
Joel Shapiro
Luojing Chen
Mary Pulvino
Michael DeRan
P2860
P304
P356
10.1182/BLOOD-2012-02-406074
P407
P577
2012-07-12T00:00:00Z