Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.
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Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivoAnalysis of inhibitor binding in influenza virus neuraminidaseNovel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active siteInfluenza Virus Neuraminidases with Reduced Enzymatic Activity That Avidly Bind Sialic Acid ReceptorsInfluenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitorsSerendipitous discovery of a potent influenza virus a neuraminidase inhibitorOral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.Molecular modeling of swine influenza A/H1N1, Spanish H1N1, and avian H5N1 flu N1 neuraminidases bound to Tamiflu and RelenzaExploring the chemical space of influenza neuraminidase inhibitorsFrom neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs?Combining crystallographic information and an aspherical-atom data bank in the evaluation of the electrostatic interaction energy in an enzyme-substrate complex: influenza neuraminidase inhibitionThe impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design.Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivirCatalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.Influenza neuraminidase: a druggable target for natural products.Peramivir: an intravenous neuraminidase inhibitor.Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site.Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.A sialosyl sulfonate as a potent inhibitor of influenza virus replication.Current landscape and future prospects of antiviral drugs derived from microbial products.Computational 3-D modeling and site-directed mutation of an antibody that binds Neu2en5Ac, a transition state analogue of a sialic acid.Sialic acid recognition by Vibrio cholerae neuraminidase.Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids.Use of conformationally restricted pyridinium alpha-D-N-acetylneuraminides to probe specificity in bacterial and viral sialidases.2D, 3D-QSAR, and pharmacophore studies on thiazolidine-4-carboxylic acid derivatives as neuraminidase inhibitors in H3N2 influenza virusInfluenza glycoproteins: Hemagglutinin and neuraminidasePhosphonate Congeners of Oseltamivir and Zanamivir as Effective Anti-influenza Drugs: Design, Synthesis and Biological Activity
P2860
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P2860
Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Molecular modeling studies on ...... nd the mechanism of catalysis.
@ast
Molecular modeling studies on ...... nd the mechanism of catalysis.
@en
Molecular modeling studies on ...... nd the mechanism of catalysis.
@nl
type
label
Molecular modeling studies on ...... nd the mechanism of catalysis.
@ast
Molecular modeling studies on ...... nd the mechanism of catalysis.
@en
Molecular modeling studies on ...... nd the mechanism of catalysis.
@nl
prefLabel
Molecular modeling studies on ...... nd the mechanism of catalysis.
@ast
Molecular modeling studies on ...... nd the mechanism of catalysis.
@en
Molecular modeling studies on ...... nd the mechanism of catalysis.
@nl
P356
P1476
Molecular modeling studies on ...... nd the mechanism of catalysis.
@en
P2093
von Itzstein M
P304
P356
10.1021/JM00031A011
P407
P577
1994-03-01T00:00:00Z