A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
about
Efficient ligation of the Schistosoma hammerhead ribozymeBis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.Energetic contribution of non-essential 5' sequence to catalysis in a hepatitis delta virus ribozymeRecent advances in the elucidation of the mechanisms of action of ribozymesA quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.High-performance liquid chromatography purification of homogenous-length RNA produced by trans cleavage with a hammerhead ribozymeSelection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA libraryThe hammerhead ribozyme: structure, catalysis, and gene regulationThe virtues of self-binding: high sequence specificity for RNA cleavage by self-processed hammerhead ribozymes.On the role of magnesium ions in RNA stability.Enhanced product stability in the hammerhead ribozyme.The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.A new assay for tRNA aminoacylation kineticsRibozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement.The 3' substrate determinants for the catalytic efficiency of the Bacillus subtilis RNase P holoenzyme suggest autolytic processing of the RNase P RNA in vivo.Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.Characterization of several kinds of dimer minizyme: simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes.Effects of variations in length of hammerhead ribozyme antisense arms upon the cleavage of longer RNA substrates.Differences in the phosphate oxygen requirements for self-cleavage by the extended and prototypical hammerhead formsThe role of an active site Mg(2+) in HDV ribozyme self-cleavage: insights from QM/MM calculations.The effect of structure in a long target RNA on ribozyme cleavage efficiency.The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis.A small modified hammerhead ribozyme and its conformational characteristics determined by mutagenesis and lattice calculation.Zinc-dependent cleavage in the catalytic core of the hammerhead ribozyme: evidence for a pH-dependent conformational changeRibozyme therapy: RNA enzymes to the rescue.Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions.Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Conformational heterogeneity and the determinants of tertiary stabilization in the hammerhead ribozyme from Dolichopoda cave crickets.Minimal Hammerhead Ribozymes with Uncompromised Catalytic ActivitySpecificity of hammerhead ribozyme cleavageIn vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiencyDesign of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene.Use of intrinsic binding energy for catalysis by an RNA enzymeA versatile cis-blocking and trans-activation strategy for ribozyme characterization.Selection of efficient cleavage sites in target RNAs by using a ribozyme expression library.Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozymeRescue of abasic hammerhead ribozymes by exogenous addition of specific bases
P2860
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P2860
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@ast
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@en
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@nl
type
label
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@ast
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@en
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@nl
prefLabel
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@ast
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@en
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@nl
P2093
P356
P1433
P1476
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction.
@en
P2093
Herschlag D
Uhlenbeck OC
P304
P356
10.1021/BI00177A031
P407
P577
1994-03-01T00:00:00Z