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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

http://www.wikidata.org/entity/Q34338564

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma Therapeutic Implications of Targeting AKT Signaling in Melanoma Phytochemicals for the Management of Melanoma RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression PTEN regulation of ERK1/2 signaling in cancer Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor.WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.Directed migration of cancer cells guided by the graded texture of the underlying matrix.Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas.The evolving role of radiation therapy in the management of malignant melanoma N-cadherin regulates mammary tumor cell migration through Akt3 suppression.Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents.Lifetime cancer risks in individuals with germline PTEN mutations.Targeting sphingosine kinase-1 to inhibit melanoma.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.AKT1 Activation Promotes Development of Melanoma Metastases.Functional effects of GRM1 suppression in human melanoma cells.Genetics of melanoma The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation.High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma.Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions.Advances in melanoma senescence and potential clinical application.Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.Modelling melanoma in mice.Genetic alterations of PTEN in human melanoma.Glutamatergic signaling in cellular transformation.PTEN and melanomagenesis.Obesity and melanoma: exploring molecular links.Melanoma metastasis: new concepts and evolving paradigms.Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.Genetics of melanoma progression: the rise and fall of cell senescence.Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers.A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts.Targeting protein kinase-b3 (akt3) signaling in melanoma.PTEN functions as a melanoma tumor suppressor by promoting host immune response.A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma.Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail.Mouse melanoma models and cell lines.

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

http://www.wikidata.org/entity/Q34338564

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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type

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

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Ubiquitination regulates PTEN nuclear import and tumor suppression

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

The Catalogue of Somatic Mutations in Cancer (COSMIC)

Pten dose dictates cancer progression in the prostate

Mutations of the BRAF gene in human cancer

A system for stable expression of short interfering RNAs in mammalian cells

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

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