Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.
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The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.FcγRIIB and autoimmunity.Mechanisms of Autoantibody-Induced Pathology.De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease.CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen.WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivoRecent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.BAFF/APRIL inhibition decreases selection of naive but not antigen-induced autoreactive B cells in murine systemic lupus erythematosusB cells and autoimmunity.Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.Testing the role of the FcγRIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response.Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.Possible influence of resistance to malaria in clinical presentation of rheumatoid arthritis: biological significance of natural selection.B-cell selection and the development of autoantibodies.Regulation of allograft survival by inhibitory FcγRIIb signalingIFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.The effect of BAFF inhibition on autoreactive B cell selection in murine SLE.Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouseFcγRIIB: a modulator of cell activation and humoral tolerance.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.The role of B lymphocyte stimulator in B cell biology: implications for the treatment of lupus.The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies.Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptor as a result of augmented humoral immunity.B cells biology in systemic lupus erythematosus-from bench to bedside.Germinal centers and autoimmune disease in humans and mice.Germinal Center B Cell Dynamics.Spontaneous germinal centers and autoimmunity.Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen-driven mutations.SHIP-1 Deficiency in AID(+) B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity.Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus.Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen.Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation.Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis.The Lupus-Associated Fcγ Receptor IIb-I232T Polymorphism Results in Impairment in the Negative Selection of Low-Affinity Germinal Center B Cells Via c-Abl in Mice
P2860
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P2860
Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@ast
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@en
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@nl
type
label
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@ast
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@en
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@nl
prefLabel
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@ast
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@en
Development of self-reactive g ...... e Fc gammaRIIB-deficient mice.
@nl
P2093
P2860
P356
P1476
Development of self-reactive g ...... ne Fc gammaRIIB-deficient mice
@en
P2093
Cornelia Kreschel
Felix Oden
Hedda Wardemann
Juliane Kofer
Maria M M Mertes
Stefan Riebel
Susanne Wickert
Thomas Tiller
P2860
P304
P356
10.1084/JEM.20100171
P407
P577
2010-11-15T00:00:00Z