The evolution of human anti-double-stranded DNA autoantibodies - Wikidata - wikimedia - TriplyDB

The evolution of human anti-double-stranded DNA autoantibodies

The evolution of human anti-double-stranded DNA autoantibodies

http://www.wikidata.org/entity/Q33878890

about

Lupus nephritis: the central role of nucleosomes revealed Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE Somatic mutagenesis in autoimmunity B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production Review: antinucleosome antibodies: a critical reflection on their specificities and diagnostic impact Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity Mutation of POLB causes lupus in mice Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans Altered B cell signalling in autoimmunity.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Covalent binding antibodies suppress advanced glycation: on the innate tier of adaptive immunity.Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.Mature B cells class switched to IgD are autoreactive in healthy individuals Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects Autoantibodies: Focus on anti-DNA antibodies.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4.Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes.Autoreactivity in human IgG+ memory B cells.Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus.B cell tolerance and positive selection in lupus.CD47 deficiency ameliorates autoimmune nephritis in Fas(lpr) mice by suppressing IgG autoantibody production.Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity.The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.Glomerular targets for autoantibodies in lupus nephritis--an apoptotic origin.Conceptual bases for quantifying the role of the environment on gene evolution: the participation of positive selection and neutral evolution.Elevated subclinical double-stranded DNA antibodies and future proliferative lupus nephritis.Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function.Functional consequences of complementarity-determining region deactivation in a multifunctional anti-nucleic acid antibody.Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouse

P2860

Q24649566-16795FC6-74E9-47A3-AA8A-0E181BC97A6C Q26767511-28B06947-F231-4A31-863E-A5BA32D45551 Q26860815-0260022F-4318-4200-A611-A170B3A9ED5A Q26996644-005B3784-F6AA-4603-8BCF-DD800547B8E0 Q27011636-1BD0D0BF-189B-41BB-A0F2-FABC72BF90F4 Q27024588-C81959A9-1614-4703-B9E0-D0207FFAA900 Q28513579-46372BA2-A692-46D2-B6E6-4F5531000660 Q30435791-838D41E0-DF03-48AA-953F-824F15B7391C Q33829729-F87AFAB3-928A-4427-BBFA-FC5DE6F82088 Q33924642-14CE90DD-E0A7-45C4-988F-58D0C71D7CA4 Q34161517-F9EEDF51-F3CA-48A0-B016-50424B24E884 Q34287672-BBCC1894-FED1-43E5-B426-24772BAC8BFC Q34339372-65CD9AF6-0130-47BD-96C2-74772705E0D2 Q34340586-4F994A5F-7D85-4EBA-8E6E-1F9756AFF2A4 Q34420821-81613225-8816-4CCE-89D4-38CB72143CA5 Q34629514-003C7A66-1769-4889-BE4B-DBFA659AC380 Q34849082-457C42AD-843F-4A55-A5A8-B5FC28D221C9 Q35106998-32272C0B-A526-4A79-BCF6-3F333CCA6CB7 Q35119826-A760B456-B03D-4772-80BD-CD6B51A4DDE7 Q35434973-1E3CF2C6-DAE3-46F6-A2F6-AA5E1F18D98E Q35677438-3FA8F236-B1FA-4756-9260-388E9A9F3D4B Q35729131-7A44FB95-7FA8-42B6-A9BB-EC5F0747EEE1 Q35821347-65A4923D-EDD7-45EA-93CE-EE984B869F47 Q35908835-38F083CE-CC5A-4105-A8C6-4EBDDDC833A2 Q36093973-A31EFC97-86BE-41F5-BD0F-0A82B3909F19 Q36166909-9054B26D-A84C-4A7F-ACFC-5E5B809C36E9 Q36253581-9788F448-B709-4B45-BDF6-3EA81D516082 Q36290338-A6998EF0-6827-4D8D-8042-EEF6E1207711 Q36393562-51FA3AF4-C976-43A2-A5E1-B9DB584CDBF4 Q36402023-B2F5F426-95D5-4294-8FED-1C663F63FA06 Q36775342-AF605724-E8DD-45AD-AC65-A6C776B9955E Q36805261-3204A740-6F39-445D-BE26-031BF110076C Q36863144-697084F6-9191-4184-8B31-ED73C3179406 Q36863150-846CD0CB-2126-4F6F-8631-1A6A4542980B Q36951005-02D4ECD2-C8BF-4346-9028-64B68AA380E2 Q36974771-07BAE684-78B4-4833-866A-1469AD0367F6 Q37212356-0347083A-58C2-49A4-BEB8-1416F6BDE70E Q37283017-D078E9B2-49EA-4ACF-BA0D-B96CB6847904 Q37388808-BBAD30F5-87EC-4B4A-BD4D-867FEBC558BA Q37395145-9722F3B9-C1A5-49A6-A20E-02D807E20173

P2860

The evolution of human anti-double-stranded DNA autoantibodies

http://www.wikidata.org/entity/Q33878890

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

The evolution of human anti-double-stranded DNA autoantibodies

@ast

The evolution of human anti-double-stranded DNA autoantibodies

@en

type

label

The evolution of human anti-double-stranded DNA autoantibodies

@ast

The evolution of human anti-double-stranded DNA autoantibodies

@en

prefLabel

The evolution of human anti-double-stranded DNA autoantibodies

@ast

The evolution of human anti-double-stranded DNA autoantibodies

@en

P1433

Q33878890-ED5A355E-80C2-4D0A-AC48-3618A4353C40

P1476

Q33878890-83AC28F3-2427-4609-A43D-C1835284DAEB

P2093

Q33878890-0F070BE6-243F-4B0E-9C9D-5DE1E02DF060

Q33878890-53037BC1-5C80-4E2F-A589-E03E7F2280C0

Q33878890-5A8F5160-C43B-4599-A3D3-8A84EB5373AA

Q33878890-96075864-75A9-458B-95F9-AE40167C3B31

Q33878890-D027D678-78E7-4564-9F05-B327A260F7EB

P2860

Q33878890-08E632F5-E742-4698-BCB4-6DA02BB0C5BB

Q33878890-08FD7DF1-FD67-49BE-9146-2509A2296A77

Q33878890-0B9E4C9A-C4DC-4E76-BDA8-3B64D1A1C010

Q33878890-1FBF6052-5C51-4AD7-B784-0B5F80A2255C

Q33878890-2B07A266-6287-42DF-B380-623D2EE71EB1

Q33878890-2D3DE0DD-8A87-4608-9E35-0524E095DB3B

Q33878890-2D9B8533-A822-4D87-917C-9A5D0D15D246

Q33878890-306E9FDA-287E-480A-82ED-463DA014AA19

Q33878890-3752A4E4-E70A-48C0-875D-6A5EF1D2E41D

Q33878890-3F4A006E-5516-4F9B-82FA-B1FB6AA2ADEB

P304

Q33878890-3C31455F-DB03-4C2C-90E6-741DEE860B82

P31

Q33878890-A78EBC0F-F4C4-44BB-AD24-02EE9C1B42CB

P356

Q33878890-C1B5CA46-7357-492C-A2D1-1745D3FC9E5F

P407

Q33878890-2BF8BAC3-378C-4524-942B-27D130112AC7

P433

Q33878890-2FF58E42-9B61-41CD-BEC3-E2CEEC2D5A29

P478

Q33878890-E9D8DBE6-EF2A-4072-A29B-6A24B36584A0

P50

Q33878890-24DCBDA0-C9CD-4017-98BC-D33BB15AE46A

P577

Q33878890-A7312C65-C8DA-45BF-8FF4-7ED7AC8097E3

P5875

Q33878890-27AC497F-C910-4706-8679-A53B5986DE59

P698

Q33878890-5470965C-0578-4AD4-B359-763EA383211B

P921

Q33878890-7A1DCEC0-C188-40D1-859F-2F6AA723CBC8

P932

Q33878890-0E566E21-3443-4FCF-807E-76ADAF69E12F

P356

PNAS.0500132102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The evolution of human anti-double-stranded DNA autoantibodies

@en

P2093

Joachim R Kalden

http://www.w3.org/2001/XMLSchema#string

Miriam Letz

http://www.w3.org/2001/XMLSchema#string

Sieglinde Angermüller

http://www.w3.org/2001/XMLSchema#string

Thomas H Winkler

http://www.w3.org/2001/XMLSchema#string

Ute Wellmann

http://www.w3.org/2001/XMLSchema#string

P2860

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Germinal centers

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.

IMGT, the international ImMunoGeneTics database.

The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies.

Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.

P304

9258-9263

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0500132102

http://www.w3.org/2001/XMLSchema#string

P407

P433

26

http://www.w3.org/2001/XMLSchema#string

P478

102

http://www.w3.org/2001/XMLSchema#string

P50

Martin Herrmann

P577

2005-06-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7775444

http://www.w3.org/2001/XMLSchema#string

P698

15968001

http://www.w3.org/2001/XMLSchema#string

P921

P932

1166593

http://www.w3.org/2001/XMLSchema#string