Mechanism-based inactivators as probes of cytochrome P450 structure and function.
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Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic ActivityPredicting in vivo drug interactions from in vitro drug discovery data.Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme.Mechanism-based inhibition of human cytochrome P4503A4 by domperidone.A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes.Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo.Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants.The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivationIn vitro approaches to investigate mechanism-based inactivation of CYP enzymes.Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.Inhibition of cytochromes p450: existing and new promising therapeutic targets.A suite of activity-based probes for human cytochrome P450 enzymes.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis.Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes.Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition.Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates.Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole.Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats.The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation.Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen.Mechanism-based inactivation of CYP2C9 by linderane.
P2860
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P2860
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@ast
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@en
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@nl
type
label
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@ast
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@en
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@nl
prefLabel
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@ast
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@en
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@nl
P2093
P356
P1476
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
@en
P2093
Hollenberg PF
Juschyshyn MI
P304
P356
10.2174/1389200013338478
P407
P577
2001-09-01T00:00:00Z